Evidence map›Paper›PMID 32680437›Full record

ArticleAnnual review of nutrition2020

From Birth and Throughout Life: Fungal Microbiota in Nutrition and Metabolic Health.

William D Fiers, Irina Leonardi, Iliyan D Iliev

Abstract read
In one paragraph

Article in Annual review of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Frontiers in immunology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William D FiersGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; email: iliev@med.cornell.edu.
Irina LeonardiGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; email: iliev@med.cornell.edu.
Iliyan D IlievGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; email: iliev@med.cornell.edu.

Funding

Commensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2M
Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity.R01DK121977 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2020 to 2024
$2.7M
Investigation of commensal bacteria-produced metabolites with activity towards mycobiota.R21AI146957 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2019 to 2020
$466k
Regulation of the mycobiota and intestinal inflammation via production of antifungal metabolites by commensal bacteriaF32DK120228 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI FIERS, WILLIAM D · 2019 to 2021
$200k
NIAID NIH HHS R21 AI146957NIDDK NIH HHS F32 DK120228NIDDK NIH HHS R01 DK113136NIDDK NIH HHS R01 DK121977
6 · The paper itself

Abstract

The human gastrointestinal tract is home to a vibrant, diverse ecosystem of prokaryotic and eukaryotic microorganisms. The gut fungi (mycobiota) have recently risen to prominence due to their ability to modulate host immunity. Colonization of the gut occurs through a combination of vertical transmission from the maternal mycobiota and environmental and dietary exposure. Data from human and animal studies demonstrate that nutrition strongly affects the mycobiota composition and that changes in the fungal communities can aggravate metabolic diseases. The mechanisms pertaining to the mycobiota's influence on host health, pathology, and resident gastrointestinal communities through intrakingdom, transkingdom, and immune cross talk are beginning to come into focus, setting the stage for a new chapter in microbiota-host interactions. Herein, we examine the inception, maturation, and dietary modulation of gastrointestinal and nutritional fungal communities and inspect their impact on metabolic diseases in humans.

Indexed as

Nutritional StatusFungiGastrointestinal MicrobiomeHost Microbial InteractionsHumansearly lifefungimetabolismmycobiotanutritiontranskingdom

Identifiers

PMID32680437
PMCPMC7529963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.