ArticleJournal of clinical medicine2020
Comprehensive Evaluation of the Oral Health Status, Salivary Gland Function, and Oxidative Stress in the Saliva of Patients with Subacute Phase of Stroke: A Case-Control Study.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Effectiveness of the "CEME" oral health intervention program for preventing stroke-associated pneumonia in patients with post-stroke dysphagia: a randomized controlled trial.BMC oral health · 2025Trial
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- Salivary chemokines and growth factors in patients with ischemic stroke.Scientific reports · 2025Article
- The screening assessment of pro-inflammatory, anti-inflammatory, Th1, Th2 and Th17 cytokines in saliva of patients with ischemic stroke.International journal of medical sciences · 2025Article
- Oral frailty subtypes and influencing factors in older patients with ischemic stroke: a latent profile analysis.Frontiers in public health · 2025Article
- The Influence of Oxidative Stress Markers in Patients with Ischemic Stroke.Biomolecules · 2024Review
- Oral health as a modifiable risk factor for cardiovascular diseases.Trends in cardiovascular medicine · 2024Review
- Impact of Smoking on Salivary Lipid Profile and Oxidative Stress in Young Adults: A Comparative Analysis between Traditional Cigarettes, E-Cigarettes, and Heat-Not-Burn Products.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Updates on the Role of Periodontitis-Related Epigenetics, Inflammation, Oral Microbiome, and Treatment in Cardiovascular Risk.Journal of inflammation research · 2024Review
- Redox Status Response of Physical Exercise Training in Women with Breast Cancer during Trastuzumab Therapy.Healthcare (Basel, Switzerland) · 2022Article
- The Link between Stroke Risk and Orodental Status-A Comprehensive Review.Journal of clinical medicine · 2022Review
- The Influence of Periodontal Diseases and the Stimulation of Saliva Secretion on the Course of the Acute Phase of Ischemic Stroke.Journal of clinical medicine · 2022Article
- Cytotoxicity of Acrylic Resins, Particulate Filler Composite Resin and Thermoplastic Material in Artificial Saliva with and without Melatonin.Materials (Basel, Switzerland) · 2022Article
- The Role of Oxidative Stress in Acute Ischemic Stroke-Related Thrombosis.Oxidative medicine and cellular longevity · 2022Review
- Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics.Frontiers in immunology · 2022Article
- Pathophysiology of Ischemic Stroke: Noncoding RNA Role in Oxidative Stress.Oxidative medicine and cellular longevity · 2022Review
- Salivary cytokine profile in patients with ischemic stroke.Scientific reports · 2021Article
- Is an Oral Health Status a Predictor of Functional Improvement in Ischemic Stroke Patients Undergoing Comprehensive Rehabilitation Treatment?Brain sciences · 2021Article
- Salivary Gland Dysfunction in Patients with Chronic Heart Failure Is Aggravated by Nitrosative Stress, as Well as Oxidation and Glycation of Proteins.Biomolecules · 2021Article
- Salivary Biomarkers of Oxidative Stress and Inflammation in Stroke Patients: From Basic Research to Clinical Practice.Oxidative medicine and cellular longevity · 2021Review
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Authors and funding
5 authors.
Funding
Abstract
This is the first study to assess, comprehensively, the oral health status; salivary glands' function and enzymatic and non-enzymatic antioxidant defense; and oxidative damage to proteins and lipids in the non-stimulated (NWS) and stimulated (SWS) whole saliva of stroke patients. The study included 30 patients in the subacute phase of the stroke and an age and gender-matched control group. We showed that the activity of antioxidant enzymes (catalase and salivary peroxidase) was significantly higher in both NWS and SWS of stroke patients, similarly to uric acid concentration. However, in the study group, the reduced glutathione (GSH) concentration in SWS decreased. The contents of protein glycooxidation products (advanced glycation end products (AGE) and protein oxidation products (AOPP)) and lipid hydroperoxides were significantly higher in NWS and SWS of stroke patients. In the study group there was also a decrease in stimulated saliva secretion and total protein content. Interestingly, products of protein and lipid oxidation correlate negatively with SWS flow. The ROC analysis showed that salivary GSH with 100% specificity and 100% sensitivity differentiates the analyzed groups (AUC = 1.0). To sum up, in subacute stroke patients there are redox imbalances and oxidative damage to proteins and lipids in non-stimulated and stimulated saliva. Stroke patients also suffer from salivary gland dysfunction.
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