Evidence map›Paper›PMID 32679905›Full record

ArticleVaccines2020

A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice.

Susan Thrane, Kara-Lee Aves, Ida E M Uddbäck, Christoph M Janitzek, Julianna Han, Yuhe R Yang, Andrew B Ward, Thor G Theander, Morten A Nielsen, Ali Salanti and 3 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Biological Nanoparticles in Vaccine Development.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. RNA Phage VLP-Based Vaccine Platforms.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Susan ThraneDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-6596-3527
Kara-Lee AvesDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-0068-7733
Ida E M UddbäckDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-6007-5918
Christoph M JanitzekDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-6529-9355
Julianna HanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-3402-2609
Yuhe R YangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-7153-3769
Thor G TheanderDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Morten A NielsenDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-2668-4992
Ali SalantiDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Allan R ThomsenDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-2392-9803
Jan P ChristensenDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-4299-9479
Adam F SanderDepartment of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-8782-7830
University of Copenhagen · DKScripps Research Institute · US

Funding

PATHOGENESIS AND IMMUNOLOGY OF DISEASET32AI007244 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 1985 to 2022
$8.8M
Independent Research Fund Denmark 6110-00177BInnovation fund Denmark 8088-00032BNIAID NIH HHS T32 AI007244
6 · The paper itself

Abstract

Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HA

Indexed as

capsid-like particlesHA-stem antigenIgG2apandemic preparednesstrimer displayuniversal influenza vaccineVirus-like particles

Identifiers

PMID32679905
PMCPMC7564254
OpenAlexW3042810850

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.