Evidence map›Paper›PMID 32679753›Full record

ArticleNutrients2020

Perinatal Docosahexaenoic Acid Supplementation Improves Cognition and Alters Brain Functional Organization in Piglets.

Xi Fang, Wenwu Sun, Julie Jeon, Michael Azain, Holly Kinder, Jeongyoun Ahn, Hee Cheol Chung, Ryan S Mote, Nikolay M Filipov, Qun Zhao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xi FangDepartment of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA 30602, USA.
Wenwu SunDepartment of Physics and Astronomy, Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA.
Julie JeonDepartment of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA 30602, USA.
Michael AzainDepartment of Animal and Dairy Science, College of Agricultural & Environmental Sciences, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-5963-7204
Holly KinderDepartment of Animal and Dairy Science, College of Agricultural & Environmental Sciences, University of Georgia, Athens, GA 30602, USA.
Jeongyoun AhnDepartment of Statistics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA.
Hee Cheol ChungDepartment of Statistics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA.
Ryan S MoteDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Nikolay M FilipovDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Qun ZhaoDepartment of Physics and Astronomy, Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-0784-1024
Srujana RayalamDepartment of Pharmaceutical Sciences, Philadelphia College of Osteopathic Medicine, Suwanee, GA 30024, USA.ORCID 0000-0003-3550-6741
Hea Jin ParkDepartment of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA 30602, USA.
University of Georgia · USPhiladelphia College of Osteopathic Medicine · US

Funding

Medical Research Council MC_PC_19009
6 · The paper itself

Abstract

Epidemiologic studies associate maternal docosahexaenoic acid (DHA)/DHA-containing seafood intake with enhanced cognitive development; although, it should be noted that interventional trials show inconsistent findings. We examined perinatal DHA supplementation on cognitive performance, brain anatomical and functional organization, and the brain monoamine neurotransmitter status of offspring using a piglet model. Sows were fed a control (CON) or a diet containing DHA (DHA) from late gestation throughout lactation. Piglets underwent an open field test (OFT), an object recognition test (ORT), and magnetic resonance imaging (MRI) to acquire anatomical, diffusion tensor imaging (DTI), and resting-state functional MRI (rs-fMRI) at weaning. Piglets from DHA-fed sows spent 95% more time sniffing the walls than CON in OFT and exhibited an elevated interest in the novel object in ORT, while CON piglets demonstrated no preference. Maternal DHA supplementation increased fiber length and tended to increase fractional anisotropy in the hippocampus of offspring than CON. DHA piglets exhibited increased functional connectivity in the cerebellar, visual, and default mode network and decreased activity in executive control and sensorimotor network compared to CON. The brain monoamine neurotransmitter levels did not differ in healthy offspring. Perinatal DHA supplementation may increase exploratory behaviors, improve recognition memory, enhance fiber tract integrity, and alter brain functional organization in offspring at weaning.

Indexed as

Dietary SupplementsAnimalsAnimals, SucklingBehavior, AnimalBiogenic MonoaminesBrainCognitionDocosahexaenoic AcidsExploratory BehaviorFemaleHippocampusLactationMagnetic Resonance ImagingMaternal-Fetal ExchangeMaternal Nutritional Physiological PhenomenaNeurotransmitter AgentsBiogenic MonoaminesDocosahexaenoic AcidsNeurotransmitter Agentsbrain developmentcognitionmaternal nutritionomega-3 fatty acidsresting state network

Identifiers

PMID32679753
PMCPMC7400913
OpenAlexW3042650470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.