Evidence map›Paper›PMID 32679751›Full record

ReviewAntioxidants (Basel, Switzerland)2020

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview.

Johura Ansary, Tamara Yuliett Forbes-Hernández, Emilio Gil, Danila Cianciosi, Jiaojiao Zhang, Maria Elexpuru-Zabaleta, Jesus Simal-Gandara, Francesca Giampieri, Maurizio Battino

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Trial
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  7. Naturally Occurring HHandbook of experimental pharmacology · 2026
    Review
  8. Article
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  10. Dietary habits and successful aging in Chinese older adults: a cross-sectional analysis of the CLHLS.Archives of public health = Archives belges de sante publique · 2025
    Article
  11. Review
  12. Article
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  14. Review
  15. Effects of a Diet ofFoods (Basel, Switzerland) · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Effect of Garlic Extract on the Erythrocyte as a Simple Model Cell.International journal of molecular sciences · 2024
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johura AnsaryDipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy.
Tamara Yuliett Forbes-HernándezNutrition and Food Science Group, department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo-Vigo Campus, 36310 Vigo, Spain.
Emilio GilNutrition and Food Science Group, Department of Biochemistry, Genetics and Immunology, Faculty of Biology, University of Vigo, 36310 Vigo, Spain.
Danila CianciosiDipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy.
Jiaojiao ZhangDipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy.
Maria Elexpuru-ZabaletaDipartimento di Scienze Cliniche e Molecolari, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy.
Jesus Simal-GandaraNutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, University of Vigo, Ourense Campus, E-32004 Ourense, Spain.
Francesca GiampieriDipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy.
Maurizio BattinoDipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.

Indexed as

garlicmetabolism and bioavailabilitypolyphenols health benefitssulfur-containing compounds

Identifiers

PMID32679751
PMCPMC7402177

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.