Evidence map›Paper›PMID 32679743›Full record

ArticleMarine drugs2020

Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells.

Rebeca Alvariño, Eva Alonso, Louis Bornancin, Isabelle Bonnard, Nicolas Inguimbert, Bernard Banaigs, Luis M Botana

Open access · goldAbstract readComparative Study
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Rebeca AlvariñoDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27003 Lugo, Spain.ORCID 0000-0001-8796-1389
Eva AlonsoDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27003 Lugo, Spain.
Louis BornancinPSL Research University: EPHE-UPVD-CNRS, USR 3278 CRIOBE, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan, France.
Isabelle BonnardPSL Research University: EPHE-UPVD-CNRS, USR 3278 CRIOBE, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan, France.
Nicolas InguimbertPSL Research University: EPHE-UPVD-CNRS, USR 3278 CRIOBE, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan, France.ORCID 0000-0002-0309-9048
Bernard BanaigsPSL Research University: EPHE-UPVD-CNRS, USR 3278 CRIOBE, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan, France.
Luis M BotanaDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27003 Lugo, Spain.ORCID 0000-0003-2153-6608
Centre National de la Recherche Scientifique · FRUniversidade de Santiago de Compostela · ES

Funding

CDTI and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad AGL2016-78728-R (AEI/FEDER, UE), ISCIII/PI16/01830 and RTC-2016-5507-2, ITC-20161072Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia GRC GI-1682 (ED431C 2017/01)European Union POCTEP 0161-Nanoeaters -1-E-1, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX
6 · The paper itself

Abstract

Laxaphycins are a family of non-ribosomal lipopeptides that have been isolated from several cyanobacteria. Some of these compounds have presented cytotoxic activities, but their mechanism of action is poorly understood. In this work, the already described laxaphycins B and B3, and acyclolaxaphycins B and B3 were isolated from the marine cyanobacteria

Indexed as

AMP-Activated Protein KinasesAntineoplastic AgentsApoptosisAutophagyCell Line, TumorDose-Response Relationship, DrugHumansInhibitory Concentration 50MitochondriaNeuroblastomaPeptides, CyclicPhosphorylationProtein ConformationStructure-Activity RelationshipTOR Serine-Threonine KinasesAMP-Activated Protein KinasesAntineoplastic AgentsLaxaphycin Blaxaphycin B3MTOR protein, humanPeptides, CyclicTOR Serine-Threonine Kinasesapoptosisautophagybiotransformationcyanobacterialaxaphycin

Identifiers

PMID32679743
PMCPMC7404270
OpenAlexW3042830579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.