Evidence map›Paper›PMID 32679647›Full record

ArticleInternational journal of molecular sciences2020

Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition.

Can-Peng Li, Yu-Xun Lu, Cheng-Ting Zi, Yu-Ting Zhao, Hui Zhao, Ya-Ping Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Pillararenes as Promising Carriers for Drug Delivery.International journal of molecular sciences · 2023
    Review
  3. Chemistry towards Biology.International journal of molecular sciences · 2023
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Can-Peng LiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.ORCID 0000-0002-1770-7796
Yu-Xun LuState Key Laboratory for Conservation and Utilization of Bio-resource, School of Life Science, Yunnan University, Kunming 650091, China.
Cheng-Ting ZiState Key Laboratory of Pu-er Tea Science, Ministry of Education in Yunnan, College of State Science, Yunnan Agricultural University, Kunming 650201, China.
Yu-Ting ZhaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Hui ZhaoState Key Laboratory for Conservation and Utilization of Bio-resource, School of Life Science, Yunnan University, Kunming 650091, China.
Ya-Ping ZhangState Key Laboratory for Conservation and Utilization of Bio-resource, School of Life Science, Yunnan University, Kunming 650091, China.
Yunnan University · CNKunming Institute of Zoology · CNYunnan Agricultural University · CN

Funding

Key Projects of Yunnan Natural Science Foundation 2018FA005Key Research and Development Projects of Yunnan 2018BC005National Natural Science Foundation of China 21565029National Natural Science Foundation of China 21764005National Natural Science Foundation of China 31760311Program for Excellent Young Talents and Donglu Scholars of Yunnan University -
6 · The paper itself

Abstract

We reported for the first time that cationic pillar[6]arene (cPA6) could tightly bind to peptide polymer (MW~20-50 kDa), an artificial substrate for tyrosine (Tyr) phosphorylation, and efficiently inhibit Tyr protein phosphorylation through host-guest recognition. We synthesized a nanocomposite of black phosphorus nanosheets loaded with cPA6 (BPNS@cPA6) to explore the effect of cPA6 on cells. BPNS@cPA6 was able to enter HepG2 cells, induced apoptosis, and inhibited cell proliferation by reducing the level of Tyr phosphorylation. Furthermore, BPNS@cPA6 showed a stronger ability of inhibiting cell proliferation in tumor cells than in normal cells. Our results revealed the supramolecular modulation of enzymatic Tyr phosphorylation by the host-guest recognition of cPA6.

Indexed as

Antineoplastic AgentsApoptosisCationsDrug CarriersHep G2 CellsHumansNanostructuresNeoplasmsPhosphorusPhosphorylationQuaternary Ammonium CompoundsTyrosineAntineoplastic AgentsCationsDrug CarriersPhosphoruspillar(6)areneQuaternary Ammonium CompoundsTyrosineapoptosismolecular recognitionpillar[6]areneprotein tyrosine phosphorylation

Identifiers

PMID32679647
PMCPMC7404071
OpenAlexW3043377014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.