ArticleNeuroImage. Clinical2020
Abnormal directed connectivity of resting state networks in focal epilepsy.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Interpretable Multiscale Directed Temporal Graph Learning for MEG-Based Identification and Lateralization of Temporal Lobe Epilepsy.Sensors (Basel, Switzerland) · 2026Article
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- Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2026Article
- Divergent Propagation Networks Define Two Pathophysiologically Distinct Electroclinical Phenotypes in Mesial Temporal Lobe Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Locating the epileptogenic zone for drug-resistant epilepsy through neuroelectrophysiological brain network topology.Frontiers in neuroscience · 2026Article
- Frequency-band specific directed connectivity networks reveal functional disruptions and pathogenic patterns in temporal lobe epilepsy: a MEG study.Scientific reports · 2025Article
- Recent applications of EEG-based brain-computer-interface in the medical field.Military Medical Research · 2025Review
- Identifying the epileptic network by linking interictal functional and structural connectivity.Scientific reports · 2025Article
- Altered structural network in temporal lobe epilepsy with focal to bilateral tonic-clonic seizures.Annals of clinical and translational neurology · 2024Article
- EEG Techniques with Brain Activity Localization, Specifically LORETA, and Its Applicability in Monitoring Schizophrenia.Journal of clinical medicine · 2024Review
- Pan-cortical electrophysiologic changes underlying attention.Scientific reports · 2024Article
- Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Lateralization of delta band power in magnetoencephalography (MEG) in patients with unilateral focal epilepsy and its relation to verbal fluency.Brain and behavior · 2023Article
- EEG biomarker candidates for the identification of epilepsy.Clinical neurophysiology practice · 2023Review
- Diagnosis of Epilepsy with Functional Connectivity in EEG after a Suspected First Seizure.Bioengineering (Basel, Switzerland) · 2022Article
- Phase-Amplitude Coupling and Phase Synchronization Between Medial Temporal, Frontal and Posterior Brain Regions Support Episodic Autobiographical Memory Recall.Brain topography · 2022Article
- Networks of cortical activity in infants with epilepsy.Brain communications · 2022Article
- Default Mode Network Resting State Connectivity Derived From Task-Based fMRI: A Validation Study in People With Epilepsy.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpilepsy diagnosis can be difficult in the absence of interictal epileptic discharges (IED) on scalp EEG. We used high-density EEG to measure connectivity in large-scale functional networks of patients with focal epilepsy (Temporal and Extratemporal Lobe Epilepsy, TLE and ETLE) and tested for network alterations during resting wakefulness without IEDs, compared to healthy controls. We measured global efficiency as a marker of integration within networks.
methodsWe analysed 49 adult patients with focal epilepsy and 16 healthy subjects who underwent high-density-EEG and structural MRI. We estimated cortical activity using electric source analysis in 82 atlas-based cortical regions based on the individual MRI. We applied directed connectivity analysis (Partial Directed Coherence) on these sources and performed graph analysis: we computed the Global Efficiency on the whole brain and on each resting state network. We tested these features in different group of patients.
resultsCompared to controls, efficiency was increased in both TLE and ETLE (p < 0.05). The somato-motor-network, the ventral-attention-network and the default-mode-network had a significantly increased efficiency (p < 0.05) in both TLE and ETLE as well as TLE with hippocampal sclerosis. SIGNIFICANCE: During interictal scalp EEG epochs without IED, patients with focal epilepsy show brain functional connectivity alterations in the whole brain and in specific resting-state-networks. This higher integration reflects a chronic effect of pathological activity within these structures and complement previous work on altered information outflow. These findings could increase the diagnostic sensitivity of scalp EEG to identify epileptic activity in the absence of IED.
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