Evidence map›Paper›PMID 32679347›Full record

ArticleJournal of the neurological sciences2020

Posterior reversible encephalopathy syndrome in patients with COVID-19.

Sarah C Parauda, Virginia Gao, Alexandra N Gewirtz, Neal S Parikh, Alexander E Merkler, Joshua Lantos, Halina White, Dana Leifer, Babak B Navi, Alan Z Segal

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the neurological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
  8. Article
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  11. Article
  12. Review
  13. Stroke Treatment in the Era of COVID-19: a Review.Current treatment options in neurology · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Neurological complications and infection mechanism of SARS-COV-2.Signal transduction and targeted therapy · 2021
    Review
  19. Article
  20. Response to correspondence concerning "Posterior reversible encephalopathy syndrome (PRES) associated with COVID-19".Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sarah C ParaudaDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
Virginia GaoDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
Alexandra N GewirtzDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
Neal S ParikhDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States of America.
Alexander E MerklerDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States of America.
Joshua LantosDepartment of Radiology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
Halina WhiteDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
Dana LeiferDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
Babak B NaviDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States of America.
Alan Z SegalDepartment of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America. Electronic address: azs2001@med.cornell.edu.
Presbyterian Hospital · USCornell University · USNew York Hospital Queens · USNewYork–Presbyterian Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report four patients with coronavirus disease 2019 (COVID-19) who developed posterior reversible encephalopathy syndrome (PRES).

methodsPatient data was abstracted from medical records at Weill Cornell Medical Center.

resultsFour patients with SARS-CoV-2 infection and PRES were identified. The patients' ages ranged from 64 to 74 years, and two were women. All four patients were admitted to the hospital with acute respiratory distress syndrome requiring intensive care unit admission and mechanical ventilation. PRES was diagnosed after persistent confusion, lethargy, new focal neurological deficits, or seizures were noted, with evidence of seizures on electroencephalogram for two of the patients. Imaging confirmed the presence of cerebral vasogenic edema. All four patients had elevated blood pressure and renal injury in the days preceding PRES diagnosis, as well as evidence of systemic inflammation and systemic hypercoagulability. Symptoms of PRES improved with blood pressure control.

conclusionsOur four cases demonstrate the occurrence of PRES in critically-ill patients with COVID-19. PRES should be considered in the differential for acute neurological deficits and seizures in this setting.

Indexed as

AgedCOVID-19FemaleHumansMaleMiddle AgedPosterior Leukoencephalopathy SyndromeRetrospective StudiesCOVID-19Posterior reversible encephalopathy syndromeSARS-CoV-2

Identifiers

PMID32679347
PMCPMC7347314
OpenAlexW3041825428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.