Evidence map›Paper›PMID 32679063›Full record

ArticleStem cell reports2020

Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis.

Ludovica F Buttó, Adam Pelletier, Shyam K More, Nan Zhao, Abdullah Osme, Christopher L Hager, Mahmoud A Ghannoum, Rafick-Pierre Sekaly, Fabio Cominelli, Maneesh Dave

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ludovica F ButtóDepartment of Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA; Department of Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Adam PelletierDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Shyam K MoreDivision of Gastroenterology & Hepatology University of California Davis, School of Medicine, Institute for Regenerative Cures, 2921 Stockton Boulevard, Suite 1615, Sacramento, CA 95817, USA.
Nan ZhaoDepartment of Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA.
Abdullah OsmeDepartment of Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Christopher L HagerCenter for Medical Mycology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Mahmoud A GhannoumCenter for Medical Mycology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Rafick-Pierre SekalyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Fabio CominelliDepartment of Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: fabio.cominelli@case.edu.
Maneesh DaveDepartment of Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA; Department of Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Division of Gastroenterology & Hepatology University of California Davis, School of Medicine, Institute for Regenerative Cures, 2921 Stockton Boulevard, Suite 1615, Sacramento, CA 95817, USA. Electronic address: mdave@ucdavis.edu.
Case Western Reserve University · USUniversity Hospitals of Cleveland · USUniversity of California, Davis · USUniversity School · US

Funding

Ubiquitination Pathways Mediating Chronic Intestinal InflammationP01DK091222 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO · 2011 to 2020
$16.5M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
MECHANISMS OF EXPERIMENTAL CROHNS DISEASER01DK055812 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2019
$4.9M
CYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7M
CYTOKINES AND INFLAMMATORY BOWEL DISEASER37DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2009
$3.8M
Polymicrobial interactions in Crohn's DiseaseR01AI145289 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GHANNOUM, MAHMOUD A · 2019 to 2023
$3.1M
Novel immunosuppressive mechanism of human bone marrow mesenchymal stem cells in experimental Crohn’s diseaseK08DK110421 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DAVE, MANEESH · 2017 to 2023
$980k
Cytokines and Inflammatory Bowel DiseaseR56DK042191 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO · 2010 to 2010
$504k
NIAID NIH HHS R01 AI145289NIDDK NIH HHS K08 DK110421NIDDK NIH HHS P01 DK091222NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS R01 DK055812NIDDK NIH HHS R37 DK042191NIDDK NIH HHS R56 DK042191
6 · The paper itself

Abstract

Intestinal epithelial barrier dysfunction is a risk factor in the pathogenesis of Crohn's disease (CD); however, no corrective FDA-approved therapies exist. We used an enteroid (EnO)-based system in two murine models of experimental CD, SAMP1/YitFc (SAMP) and TNF

Indexed as

Stem Cell NicheAnimalsCrohn DiseaseCulture Media, ConditionedDexamethasoneDisease Models, AnimalGene Expression RegulationIleitisInflammationIntestinal MucosaIntestine, SmallMaleMice, Inbred C57BLOrganoidsSignal TransductionStem CellsCulture Media, ConditionedDexamethasoneTumor Necrosis Factor-alphaWnt3A ProteinCrohn’s diseaseenteroidsepithelial barrier defectintestinal stem cell nicheorganoidsPaneth cellsRNAseqSAMP1/YitFcstem cellsTNF(ΔARE)

Identifiers

PMID32679063
PMCPMC7419719
OpenAlexW3042668911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.