Evidence map›Paper›PMID 32678707›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium.

Gregory S Hoeker, Carissa C James, Allison N Tegge, Robert G Gourdie, James W Smyth, Steven Poelzing

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Clinical significance of R-wave amplitude in lead VAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
    Article
  12. Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  13. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  14. Article
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  19. Hypernatremia and intercalated disc edema synergistically exacerbate long-QT syndrome type 3 phenotype.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gregory S HoekerCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia.
Carissa C JamesCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia.
Allison N TeggeVirginia Tech Carilion School of Medicine, Roanoke, Virginia.
Robert G GourdieCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia.
James W SmythCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia.ORCID 0000-0003-4246-7904
Steven PoelzingCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia.
Carilion Roanoke Memorial Hospital · USCarilion Clinic · US

Funding

PATTERNING OF GAP JUNCTION COUPLING IN DEVELOPING HEARTR01HL056728 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G · 1997 to 2021
$5.6M
Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Signaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6M
Translation initiation in cardiac intercellular communication and stress-induced remodelingR01HL132236 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SMYTH, JAMES WILLIAM · 2017 to 2021
$2.0M
The Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8M
Altered translation initiation in regulation of gap junction couplingF31HL140909 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JAMES, CARISSA · 2018 to 2019
$55k
NHLBI NIH HHS F31 HL140909NHLBI NIH HHS R01 HL056728NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL132236NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855
6 · The paper itself

Abstract

Myocardial ischemia leads to conduction slowing, cell-to-cell uncoupling, and arrhythmias. We previously demonstrated that varying perfusate sodium (Na

Indexed as

Heart RateAction PotentialsAnimalsBradycardiaCalciumCoronary CirculationDisease Models, AnimalGuinea PigsHeart BlockHeart Conduction SystemIsolated Heart PreparationMaleMyocardial IschemiaSignal TransductionSodiumTime FactorsCalciumSodiumarrhythmiacalciumconductionischemiasodium

Identifiers

PMID32678707
PMCPMC7473923
OpenAlexW3042949406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.