ReviewEye (London, England)2021
A review of imaging modalities for detecting early keratoconus.
Review in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Smartphone-Assisted Placido Ring Imaging for K1 Stratification in Keratoconus: A Deep Learning Study.Diagnostics (Basel, Switzerland) · 2026Article
- A deep learning approach for keratoconus detection using spatio-temporal features from corneal imaging.Scientific reports · 2026Article
- Article
- Prevalence and Risk Factors for Keratoconus in Young Adults Assessed with Tomography and Corneal Biomechanics: A Prospective Cross-Sectional Study.Ophthalmology science · 2026Article
- Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for At-Risk Populations.Ophthalmology science · 2026Review
- Scheimpflug tomographic changes across the keratoconus spectrum based on the modified Rabinowitz-McDonnell classification.European journal of medical research · 2026Article
- [Diagnostic innovations for the early detection and characterization of keratoconus].Die Ophthalmologie · 2026Review
- Artificial Intelligence Application in Cornea and External Diseases.Diagnostics (Basel, Switzerland) · 2025Review
- Deep Learning-Based Diagnosis of Corneal Condition by Using Raw Optical Coherence Tomography Data.Diagnostics (Basel, Switzerland) · 2025Article
- Delayed corneal haze after combined photorefractive keratectomy and corneal cross-linking in non-keratoconus patients.International ophthalmology · 2025Article
- Machine learning-assisted early detection of keratoconus: a comparative analysis of corneal topography and biomechanical data.Scientific reports · 2025Article
- Highly efficient stacking ensemble learning model for automated keratoconus screening.Eye and vision (London, England) · 2025Article
- Corneal Topography - a Review of Available Investigation Methods and Impact in the Diagnosis and Follow-Up of Keratoconus.Maedica · 2025Article
- Assessing UVA and Laser-Induced Crosslinking via Brillouin Microscopy.Journal of biophotonics · 2025Article
- Application of multimodal large language models for safety indicator calculation and contraindication prediction in laser vision correction.NPJ digital medicine · 2025Article
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
- Intraocular pressure and ocular biomechanical parameters vary between generations of the ocular response analyzer in healthy and ectatic eyes.Frontiers in medicine · 2025Article
- Artificial intelligence in corneal diseases: A narrative review.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2024Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEarly identification of keratoconus is imperative for preventing iatrogenic corneal ectasia and allowing for early corneal collagen cross-linking treatments to potentially halt progression and decrease transplant burden. However, early diagnosis of keratoconus is currently a diagnostic challenge as there is no uniform screening criteria. We performed a review of the current literature to assess imaging modalities that can be used to help identify subclinical keratoconus.
methodsA Pubmed database search was conducted. We included primary and empirical studies for evaluating different modalities of screening for subclinical keratoconus.
resultsA combination of multiple imaging tools, including corneal topography, tomography, Scheimpflug imaging, anterior segment optical coherence tomography, and in vivo confocal microscopy will allow for enhanced determination of subclinical keratoconus. In patients who are diagnostically borderline using a single screening criteria, use of additional imaging techniques can assist in diagnosis. Modalities that show promise but need further research include polarization-sensitive optical coherence tomography, Brillouin microscopy, and atomic force microscopy.
conclusionsRecognition of early keratoconus can reduce risk of post-refractive ectasia and reduce transplantation burden. Though there are no current uniform screening criterion, multiple imaging modalities have shown promise in assisting with the early detection of keratoconus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.