Evidence map›Paper›PMID 32678335›Full record

ArticleThe Journal of antibiotics2020

In vitro activity of radezolid against Enterococcus faecium and compared with linezolid.

Zhichao Xu, Ying Wei, Yu Wang, Guangjian Xu, Hang Cheng, Junwen Chen, Zhijian Yu, Zhong Chen, Jinxin Zheng

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhichao Xu *Department of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
Ying Wei *Heilongjiang Medical Service Management Evaluation Center, Harbin, Heilongjiang, 150031, China.
Yu Wang *Department of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
Guangjian XuDepartment of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
Hang ChengDepartment of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
Junwen ChenDepartment of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
Zhijian YuDepartment of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
Zhong ChenDepartment of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China. cchen17@fudan.edu.cn.
Jinxin ZhengDepartment of Infectious Diseases and Shenzhen key laboratory for endogenous infections, Shenzhen Nanshan people's Hospital, Shenzhen University of School Medicine, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China. jinxinzheng@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4064-2430
Shenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to explore the antimicrobial activity and resistance mechanism of radezolid against Enterococcus faecium, and to compare it with linezolid. A total of 232 E. faecium isolates were collected, and the minimal inhibitory concentrations of radezolid and linezolid were determined. The radezolid- or linezolid-nonsusceptible isolates were selected by passage in vitro under antibiotic pressure. Oxazolidinone-resistant chromosomal genes and plasmid-borne genes cfr, optrA, and poxtA were detected by PCR and sequenced. Radezolid MIC

Indexed as

Drug Resistance, BacterialEnterococcus faeciumGenes, BacterialLinezolidMicrobial Sensitivity TestsMultilocus Sequence TypingOxazolidinonesRNA, Ribosomal, 23SLinezolidOxazolidinonesradezolidRNA, Ribosomal, 23S

Identifiers

PMID32678335
OpenAlexW3043083953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.