ArticleInternational journal of obesity (2005)2020
Cross-sectional associations between central and general adiposity with albuminuria: observations from 400,000 people in UK Biobank.
Article in International journal of obesity (2005), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.Clinical chemistry · 2022Pooled it
- Albuminuria: the missing therapeutic target in obesity care.International journal of obesity (2005) · 2026Review
- Biomarkers in Diabetic Kidney Disease: Early Detection, Prognostic Assessment, and Integration with Multi-Omics Signatures.Life (Basel, Switzerland) · 2026Review
- Combined impact of microalbuminuria and obesity on cardiovascular outcomes in hospitalized heart failure patients: a cohort study.BMC cardiovascular disorders · 2026Observational
- Very low-grade albuminuria is linked to arterial stiffness in a population-based cohort.American journal of preventive cardiology · 2026Article
- Perinephric fat volume and its negative correlation with the eGFR according to a population health screening: a cross-sectional study.Renal failure · 2025Article
- Association between adiposity indices and incident albuminuria: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).BMC nephrology · 2025Article
- Can screening for albuminuria detect type 2 diabetes mellitus?Kidney research and clinical practice · 2025Article
- Malnutrition in Elderly Patients with Chronic Kidney Disease-The Role of Albuminuria.Life (Basel, Switzerland) · 2025Article
- Cardiovascular-kidney-metabolic syndrome modifies smoking-related risk for cardiovascular diseases: findings from an observational cohort study in UK Biobank.BMC public health · 2025Observational
- Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review.Circulation · 2025Review
- Obesity-Related Kidney Disease in Bariatric Surgery Candidates.Obesity surgery · 2025Article
- Risk of new-onset diabetes and efficacy of pharmacological weight loss therapy.Diabetes, obesity & metabolism · 2024Article
- Kidney shape statistical analysis: associations with disease and anthropometric factors.BMC nephrology · 2023Article
- Renal Dysfunction Phenotypes in Patients Undergoing Obesity Surgery.Biomolecules · 2023Article
- Management of obesity across women's life course: FIGO Best Practice Advice.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023Article
- Article
- Article
- Lipid Accumulation Product is Associated with Urinary Albumin-creatinine Ratio in Chinese Prediabitic Population: A Report from the REACTION Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundWhether measures of central adiposity are more or less strongly associated with risk of albuminuria than body mass index (BMI), and by how much diabetes/levels of glycosylated haemoglobin (HbA1c) explain or modify these associations, is uncertain.
methodsOrdinal logistic regression was used to estimate associations between values of central adiposity (waist-to-hip ratio) and, separately, general adiposity (BMI) with categories of urinary albumin-to-creatinine ratio (uACR) in 408,527 UK Biobank participants. Separate central and general adiposity-based models were initially adjusted for potential confounders and measurement error, then sequentially, models were mutually adjusted (e.g. waist-to-hip ratio adjusted for BMI, and vice versa), and finally they were adjusted for potential mediators.
resultsLevels of albuminuria were generally low: 20,425 (5%) had a uACR ≥3 mg/mmol. After adjustment for confounders and measurement error, each 0.06 higher waist-to-hip ratio was associated with a 55% (95%CI 53-57%) increase in the odds of being in a higher uACR category. After adjustment for baseline BMI, this association was reduced to 32% (30-34%). Each 5 kg/m
conclusionsConventional epidemiological approaches suggest that higher waist-to-hip ratio and BMI are independently positively associated with albuminuria. Adiposity-albuminuria associations appear strong among people with normal HbA1c, as well as people with pre-diabetes or diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.