Evidence map›Paper›PMID 32678187›Full record

ArticleScientific reports2020

Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis.

Baihui Zhao, Yongkun Chen, Mo Li, Jianfang Zhou, Zheng Teng, Jian Chen, Xue Zhao, Hao Wu, Tian Bai, Shenghua Mao and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 2 countries.

Baihui Zhao *Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Yongkun Chen *School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 510275, China.
Mo Li *Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Jianfang Zhou *National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health Commission, Beijing, 102206, China.
Zheng TengShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200036, China.
Jian ChenShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200036, China.
Xue ZhaoShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200036, China.
Hao WuBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Tian BaiNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health Commission, Beijing, 102206, China.
Shenghua MaoShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200036, China.
Fanghao FangShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200036, China.
Wei ChuShanghai Huangpu District Center for Disease Control and Prevention, Shanghai, 200023, China.
Hailiang HuangAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Cong HuaiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Lu ShenBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Wei ZhouBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Liangdan SunDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, 230032, China.
Xiaodong ZhengDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, 230032, China.
Guangxia ChengJinan Infectious Disease Hospital, Jinan, 250021, China.
Ye SunJinan Infectious Disease Hospital, Jinan, 250021, China.
Dayan WangNational Institute for Viral Disease Control and Prevention China CDC, Beijing, 102206, China.
Lin HeBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
Yuelong ShuSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 510275, China. shuylong@mail.sysu.edu.cn.
Xi ZhangShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200036, China. zhangxi@scdc.sh.cn.
Shengying QinBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China. chinsir@sjtu.edu.cn.
Shanghai Jiao Tong University · CNShanghai Municipal Center For Disease Control Prevention · CNAnhui Medical University · CNJinan Infectious Disease Hospital · CNNational Institute for Viral Disease Control and Prevention · CNSun Yat-sen University · CNBroad Institute · USChinese Center For Disease Control and Prevention · CNJining Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The A(H7N9) virus strain that emerged in 2013 was associated with a high fatality rate and may become a long-term threat to public health. A(H7N9) disease incidence is disproportionate to viral exposure, suggesting that host genetic factors may significantly influence susceptibility to A(H7N9) infection. Human genome variation in conferring risk for A(H7N9) infection in Chinese populations was identified by a two-stage investigation involving 121 A(H7N9) patients and 187 healthy controls using next generation sequencing followed by functional analysis. As a result, a low frequency variant (rs189256251; P = 0.0303, OR = 3.45, 95% CI 1.05-11.35, chi-square test) and three HLA alleles (DQB1*06:01, DQA1*05:05 and C*12:02) were identified in A(H7N9) infected volunteers. In an A549 cell line carrying the rs189256251 variant CT genotype, A(H7N9) infection incidence was elevated 6.665-fold over control cells carrying the CC genotype. Serum levels of interferon alpha were significantly lower in patients with the CT genotype compared to the CC genotype (P = 0.01). The study findings of genetic predisposition to A(H7N9) in the Chinese population may be valuable in systematic investigations of A(H7N9) disease etiology.

Indexed as

Genetic LociGenetic Predisposition to DiseaseHost-Pathogen InteractionsInfluenza A Virus, H7N9 SubtypeAdultAllelesGene FrequencyGenotypeHigh-Throughput Nucleotide SequencingHumansInfluenza, HumanMale

Identifiers

PMID32678187
PMCPMC7366728
OpenAlexW3043686723

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.