ArticleNature communications2020
The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
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- Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae.Communications biology · 2025Article
- Acute fibrinous and organizing pneumonia induced by cat scratch disease: a first case report.Frontiers in medicine · 2025Article
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- Neurobartonelloses: emerging from obscurity!Parasites & vectors · 2024Review
- Genome sequences of threeMicrobiology resource announcements · 2024Article
- Genomic properties of a Bartonella quintana strain from Japanese macaque (Macaca fuscata) revealed by genome comparison with human and rhesus macaque strains.Scientific reports · 2024Article
- IsLeukemia research reports · 2024Review
- Viable but nonculturable state in the zoonotic pathogenFrontiers in cellular and infection microbiology · 2024Article
- Comparison of Biological Activities of BafA Family Autotransporters withinInfection and immunity · 2023Article
- Advancements in understanding the molecular and immune mechanisms ofFrontiers in microbiology · 2023Review
- Interference of flagellar rotation up-regulates the expression of small RNA contributing toScience advances · 2022Article
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- Advances in hydrogel-based vascularized tissues for tissue repair and drug screening.Bioactive materials · 2022Review
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- Melanin Produced bymSphere · 2021Article
- The Continuing Ophthalmic Challenge ofOphthalmology science · 2021Article
- Bartonella henselae Persistence within Mesenchymal Stromal Cells Enhances Endothelial Cell Activation and Infectibility That Amplifies the Angiogenic Process.Infection and immunity · 2021Article
- Comparison of Serological and Molecular Assays forPathogens (Basel, Switzerland) · 2021Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. The underlying mechanisms are unclear, but involve secretion of an unidentified mitogenic factor. Here, we use functional transposon-mutant screening in Bartonella henselae to identify such factor as a pro-angiogenic autotransporter, called BafA. The passenger domain of BafA induces cell proliferation, tube formation and sprouting of microvessels, and drives angiogenesis in mice. BafA interacts with vascular endothelial growth factor (VEGF) receptor-2 and activates the downstream signaling pathway, suggesting that BafA functions as a VEGF analog. A BafA homolog from a related pathogen, Bartonella quintana, is also functional. Our work unveils the mechanistic basis of vasoproliferative lesions observed in bartonellosis, and we propose BafA as a key pathogenic factor contributing to bacterial spread and host adaptation.
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