Evidence map›Paper›PMID 32678078›Full record

ArticleBlood cancer journal2020

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium.

J M Sánchez-Maldonado, D Campa, J Springer, J Badiola, Y Niazi, A Moñiz-Díez, F Hernández-Mohedo, P González-Sierra, R Ter Horst, A Macauda and 30 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cancer journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 17 institutions in 8 countries.

J M Sánchez-MaldonadoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.
D CampaDepartment of Genetics, University of Pisa, Pisa, Italy.
J SpringerUniversitätsklinikum Würzburg, Medizinische Klinik II, Würzburg, Germany.
J BadiolaHematology department, Virgen de las Nieves University Hospital, Granada, Spain.ORCID http://orcid.org/0000-0003-0660-9186
Y NiaziDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
A Moñiz-DíezGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.
F Hernández-MohedoHematology department, Virgen de las Nieves University Hospital, Granada, Spain.
P González-SierraHematology department, Virgen de las Nieves University Hospital, Granada, Spain.ORCID http://orcid.org/0000-0002-6492-1728
R Ter HorstDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
A MacaudaDepartment of Genetics, University of Pisa, Pisa, Italy.
S BrezinaInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5238-6900
C CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
M LacknerDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
M A López-NevotImmunology department, Virgen de las Nieves University Hospital, Granada, Spain.
L FianchiIstituto di Ematologia, Università Cattolica del S. Cuore, Rome, Italy.
L PaganoDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, Modena, Italy.ORCID http://orcid.org/0000-0001-8287-928X
E López-FernándezHematology department, Virgen de las Nieves University Hospital, Granada, Spain.
L PotenzaDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, Modena, Italy.
M LuppiDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, Modena, Italy.
L MoratallaHematology department, Virgen de las Nieves University Hospital, Granada, Spain.
J J Rodríguez-SevillaHematology department, Hospital del Mar, Barcelona, Spain.
J E FonsecaRheumatology and Metabolic Bone Diseases department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.
M TormoHematology department, Hospital Clinico Universitario-INCLIVA, University of Valencia, Valencia, Spain.
C SolanoHematology department, Hospital Clinico Universitario-INCLIVA, University of Valencia, Valencia, Spain.
E ClaveroHematology department, Virgen de las Nieves University Hospital, Granada, Spain.
A RomeroHematology department, Virgen de las Nieves University Hospital, Granada, Spain.
Y LiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
C Lass-FlörlDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
H EinseleUniversitätsklinikum Würzburg, Medizinische Klinik II, Würzburg, Germany.
L VazquezHematology department, University Hospital of Salamanca, Salamanca, Spain.
J LoefflerUniversitätsklinikum Würzburg, Medizinische Klinik II, Würzburg, Germany.
K HemminkiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
A CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID http://orcid.org/0000-0001-8935-8030
M G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
A GsurInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-9795-1528
C DumontetUniversité Claude Bernard Lyon I, Lyon, France.
F CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
A FörstiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
M Jurado *Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.
J Sainz *Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain. juan.sainz@genyo.es.ORCID http://orcid.org/0000-0002-9355-2423
Universidad de Granada · ESGerman Cancer Research Center · DEHospital Universitario Virgen de las Nieves · ESUniversitätsklinikum Würzburg · DEUniversity of Modena and Reggio Emilia · ITCentro de Computação Gráfica · PTInnsbruck Medical University · ATMedical University of Vienna · ATRadboud University Nijmegen · NLUniversitat de València · ESUniversity of Pisa · ITHospital Del Mar · ESUniversidad de Salamanca · ESUniversità Cattolica del Sacro Cuore · ITUniversité Claude Bernard Lyon 1 · FRUniversity of Bonn · DEUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13

Indexed as

Disease SusceptibilityGenetic VariationAdultAgedAllelesBiomarkers, TumorFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansImmunityImmunomodulationLeukemia, Myeloid, AcuteMaleMiddle AgedBiomarkers, TumorSteroids

Identifiers

PMID32678078
PMCPMC7366925
OpenAlexW3043508053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.