Evidence map›Paper›PMID 32678050›Full record

ArticleParticle and fibre toxicology2020

Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation".

Kevin E Driscoll, Paul A Borm, Ishrat Chaudhuri, Len Levy, Mei Yong, David Warheit, Robert McCunney, Günter Oberdörster

Abstract readLetterComment
In one paragraph

Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kevin E DriscollErnest Mario School of Pharmacy, Rutgers, New Brunswick, NY, 07046, USA. kevinedriscoll1@gmail.com.ORCID 0000-0002-4544-9122
Paul A BormNanoconsult, Meerssen, Netherlands.
Ishrat ChaudhuriCabot Corporation, Billerica, MA, USA.
Len LevyCranfield University, Cranfield, UK.
Mei YongMY EpiConsulting, Düsseldorf, Germany.
David WarheitWarheit Scientific LLC, Wilmington, Delaware, USA.
Robert McCunneyPulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Günter OberdörsterSchool of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the science is recounted accurately it does not support Saber et al's statements and conclusions.

Indexed as

LungLung NeoplasmsAdministration, InhalationAnimalsRats

Identifiers

PMID32678050
PMCPMC7367332

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.