Evidence map›Paper›PMID 32677875›Full record

Observational studyRadiology2020

Retrospective Observational Study of Brain MRI Findings in Patients with Acute SARS-CoV-2 Infection and Neurologic Manifestations.

Lydia Chougar, Natalia Shor, Nicolas Weiss, Damien Galanaud, Delphine Leclercq, Bertrand Mathon, Samia Belkacem, Sebastian Ströer, Sonia Burrel, David Boutolleau and 17 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 15 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 15 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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  6. Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  10. COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
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  15. Neurological manifestations of coronavirus infections - a systematic review.Annals of clinical and translational neurology · 2020
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 1 institution in 1 country.

Lydia ChougarFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0001-9306-5687
Natalia ShorFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0003-0693-1829
Nicolas WeissFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0001-5155-196X
Damien GalanaudFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-9285-8121
Delphine LeclercqFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0003-1110-3833
Bertrand MathonFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-9182-5846
Samia BelkacemFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-3634-912X
Sebastian StröerFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).
Sonia BurrelFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-7783-2601
David BoutolleauFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0001-9401-4662
Alexandre DemouleFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-0432-7217
Charlotte RossoFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0001-7236-1508
Cécile DelormeFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-5838-9077
Danielle SeilheanFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0003-3498-4602
Didier DormontFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-6080-1286
Elise MorawiecFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-1323-6819
Mathieu RauxFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0003-2493-9146
Sophie DemeretFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-0523-6472
Sophie GerberFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-1901-8126
Stéphanie TrunetFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0003-3825-7699
Thomas SimilowskiFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0003-2868-9279
Vincent DegosFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-6540-5725
Pierre RufatFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-2222-4369
Jean-Christophe CorvolFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0001-7325-0199
Stéphane LehéricyFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-5802-3518
Nadya PyatigorskayaFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).ORCID 0000-0002-2070-1299
CoCo Neurosciences Study GroupFrom the Sorbonne Université, Inserm, CNRS, Institut du Cerveau-Paris Brain Institute (ICM), F-75013 Paris, France (L.C., D.G., B.M., C.R., D.D., J.C.C., S.L., N.P.); Sorbonne Université, INSERM 75013 Paris, France (L.C., N.S., N.W., D.G., B.M., S. Burrel, D.B., A.D., C.R., D.S., D.D., E.M., M.R., T.S., V.D., J.C.C., S.L., N.P.); Paris Brain Institute - ICM, Movement Investigations and Therapeutics Team (MOV'IT), Paris, France (L.C., S.L., N.P.); ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France (L.C., D.G., S.L., N.P.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Service de Neuroradiologie (L.C., N.S., D.G., D.L., S. Belkacem, S.S., D.D., S.G., S.T., S.L., N.P.), Médecine Intensive Réanimation Neurologique (N.W.), Service de Neurochirurgie (B.M.), Service de Virologie, Centre d'Investigation Clinique Neurosciences (S. Burrel, D.B.), Service de Pneumologie, Médecine Intensive et Réanimation (A.D., E.M., T.S.), Urgences Cérébro-Vasculaires (C.R.), Département de Neurologie, Centre d'Investigation Clinique Neurosciences (C.D., J.C.C.), Département de Neuropathologie (D.S.), Department of Anesthesia, Critical Care and Peri-Operative Medicine (M.R., V.D.), Paris, France; Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition (N.W., S.D.); CNR Herpèsvirus (laboratoire associé HSV), SU-INSERM UMR_S 1136 Team 3 THERAVIR IPLESP (S. Burrel, D.B.); ICM, Stroke Network, STAR Team, Paris, France (C.R.); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière,; ICM, INRIA, ARAMIS project-team, Paris, France (D.D., M.R.); Clinical Research Group ARPE, Sorbonne University, Paris, France (V.D.); INSERM UMR 1141, Paris France (V.D.); and Assistance Publique Hôpitaux de Paris, DMU ESPRIT, Paris, France (P.R.).
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background This study provides a detailed imaging assessment in a large series of patients infected with coronavirus disease 2019 (COVID-19) and presenting with neurologic manifestations. Purpose To review the MRI findings associated with acute neurologic manifestations in patients with COVID-19. Materials and Methods This was a cross-sectional study conducted between March 23 and May 7, 2020, at the Pitié-Salpêtrière Hospital, a reference center for COVID-19 in the Paris area. Adult patients were included if they had a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with acute neurologic manifestations and referral for brain MRI. Patients with a prior history of neurologic disease were excluded. The characteristics and frequency of different MRI features were investigated. The findings were analyzed separately in patients in intensive care units (ICUs) and other departments (non-ICU). Results During the inclusion period, 1176 patients suspected of having COVID-19 were hospitalized. Of 308 patients with acute neurologic symptoms, 73 met the inclusion criteria and were included (23.7%): thirty-five patients were in the ICU (47.9%) and 38 were not (52.1%). The mean age was 58.5 years ± 15.6 [standard deviation], with a male predominance (65.8% vs 34.2%). Forty-three patients had abnormal MRI findings 2-4 weeks after symptom onset (58.9%), including 17 with acute ischemic infarct (23.3%), one with a deep venous thrombosis (1.4%), eight with multiple microhemorrhages (11.3%), 22 with perfusion abnormalities (47.7%), and three with restricted diffusion foci within the corpus callosum consistent with cytotoxic lesions of the corpus callosum (4.1%). Multifocal white matter-enhancing lesions were seen in four patients in the ICU (5%). Basal ganglia abnormalities were seen in four other patients (5%). Cerebrospinal fluid analyses were negative for SARS-CoV-2 in all patients tested (

Indexed as

Acute DiseaseAdultAgedAged, 80 and overBetacoronavirusBrainCerebrovascular DisordersCoronavirus InfectionsCOVID-19Cross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPandemics

Identifiers

PMID32677875
PMCPMC7370354
OpenAlexW3043572756

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