ArticleClinical and translational gastroenterology2020
Endoscopic Ultrasound-Guided Coil Embolization With Absorbable Gelatin Sponge Appears Superior to Traditional Cyanoacrylate Injection for the Treatment of Gastric Varices.
Article in Clinical and translational gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07699354 (Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Endoscopic Treatment of Gastric Varices), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Endoscopic Treatment of Gastric Varices (CoAGS-GV): A Randomized, Patient- and Assessor-Blinded, Non-Inferiority Trial
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Diagnostic and therapeutic role of endoscopic ultrasound in liver diseases: A systematic review and meta-analysis.World journal of gastroenterology · 2024Pooled it
- Endoscopic ultrasonography-guided injection of cyanoacrylate in the treatment of gastroesophageal varices type 1: a single-center randomized study.Surgical endoscopy · 2023Trial
- EUS-guided esophagogastric variceal obliteration: real-world cohort of three generation glue embolization (with video).Surgical endoscopy · 2026Article
- A Technical Review of EUS-Guided Variceal Eradication.Clinical and translational gastroenterology · 2026Review
- Endohepatology: Current perspectives and future directions.Hepatology communications · 2025Review
- Cyanoacrylate injection assisted by endosonographic mini-probe in the management of gastric varices: a single-center, retrospective cohort study.Surgical endoscopy · 2025Article
- Advances in Endo-Hepatology: The Role of Endoscopic Ultrasound in the Management of Portal Hypertension.Diagnostics (Basel, Switzerland) · 2025Review
- Technical tips for EUS-guided embolization of varices and pseudoaneurysms.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Review
- EUS-Guided Combined Injection Therapy as a Secondary Prophylaxis of Gastric Variceal Bleeding in a Patient Contraindicated for TIPS: Case Report.Medicina (Kaunas, Lithuania) · 2024Article
- Efficacy and safety of EUS-guided coil embolization in combination with cyanoacrylate injection versus conventional endoscopic cyanoacrylate injection in the treatment of gastric varices with spontaneous portosystemic shunts.Gastroenterology report · 2024Article
- Article
- Therapeutic Endoscopic Ultrasound: Current Indications and Future Perspectives.GE Portuguese journal of gastroenterology · 2023Review
- Endoscopic ultrasound-guided vascular interventions: An expanding paradigm.World journal of gastrointestinal endoscopy · 2023Review
- The Role of Endoscopic Ultrasound in Hepatology.Gut and liver · 2023Review
- EUS-Guided Vascular Interventions.Journal of clinical medicine · 2023Review
- Comparison of efficacy and safety of endoscopic and radiological interventions for gastric varices: A systematic review and network meta-analysis.Clinical and experimental hepatology · 2023Article
- Endoscopic ultrasound-guided diagnosis and treatment of gastric varices.World journal of gastrointestinal endoscopy · 2022Review
- Modified endoscopic ultrasound-guided selective N-butyl-2-cyanoacrylate injections for gastric variceal hemorrhage in left-sided portal hypertension: A case report.World journal of clinical cases · 2022Article
- Role of endoscopic ultrasound in vascular interventions: Where are we now?World journal of gastrointestinal endoscopy · 2022Review
- Optimal Treatment for Patients With Cavernous Transformation of the Portal Vein.Frontiers in medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGastric variceal (GV) bleeding is a feared complication of cirrhosis. Traditional endoscopic treatment with cyanoacrylate (CYA) injection can be challenging. Alternatively, endoscopic ultrasound (EUS)-guided delivery of hemostatic coils has shown high therapeutic success without the complications profile of CYA alone. Our aim was to compare the clinical outcomes of EUS-guided coil embolization with endoscopic CYA injection for the treatment of GV.
methodsWe performed a matched cohort study using a prospective registry involving 2 tertiary centers. A total of 10 patients undergoing EUS-based coil therapy were matched in 1:3 fashion to 30 patients who underwent CYA injection. The matching criteria included type of GV, Charlson comorbidity index, and bleeding severity. Primary outcomes were technical success and complications. Secondary outcomes were rebleeding rates, reinterventions rates, total transfusion requirements, and time-to-event analysis (rebleeding, reintervention, and transfusion).
resultsTechnical success was 100% for EUS coil therapy vs 96.7% for CYA injection (P = 1.0). Complication rates were 10% in the EUS coil group vs 20% in the CYA group; P = 0.65. At 9 months, no EUS coil patient had rebled compared with 38% of the CYA group. No EUS coil patient required blood transfusion for GV rebleed, whereas over 50% of CYA patients did. Ten percent of EUS coil patients required reintervention compared with 60% of CYA patients. The EUS coil group had superior time to reintervention, GV rebleed, and transfusions (all P < 0.05). DISCUSSION: Compared with CYA, EUS-guided coil injection appears superior for the treatment of GV and should be considered initial endoscopic treatment of choice in centers with interventional EUS expertise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.