Evidence map›Paper›PMID 32677592›Full record

ArticleDevelopment and psychopathology2020

Trajectories of co-occurring psychopathology symptoms in autism from late childhood to adulthood.

James B McCauley, Rebecca Elias, Catherine Lord

Abstract read
In one paragraph

Article in Development and psychopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Executive function challenges persist into young adulthood and predict mental health outcomes in autism.Journal of child psychology and psychiatry, and allied disciplines · 2026
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  14. Spanish Validation of the Autism Spectrum Quotient for Children (AQ-Child-SV).Journal of autism and developmental disorders · 2025
    Article
  15. Article
  16. Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence.Autism research : official journal of the International Society for Autism Research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James B McCauleyDepartment of Psychiatry, University of California, Los Angeles, CA, USA.
Rebecca EliasDepartment of Psychiatry, University of California, Los Angeles, CA, USA.
Catherine LordDepartment of Psychiatry, University of California, Los Angeles, CA, USA.

Funding

Transitioning to Adulthood: A Prospective Longitudinal StudyR01HD081199 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2015 to 2019
$3.1M
Longitudinal Studies of Autism Spectrum Disorders: 2 to 23R01MH081873 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2008 to 2012
$2.7M
NICHD NIH HHS R01 HD081199NIMH NIH HHS R01 MH081873
6 · The paper itself

Abstract

Given high rates of co-occurring conditions in youth and adults with autism spectrum disorder (ASD), it is critical to examine the developmental trajectories of these symptoms of psychopathology. Using data from a cohort of participants (n = 194), most of whom were first assessed for ASD in very early childhood, we investigated the trajectories of co-occurring depressive, anxiety, and attention-deficit hyperactivity disorder (ADHD) symptoms from late childhood to adulthood. Additionally, childhood predictors and adult outcomes associated with these symptom trajectories were examined. Using group-based trajectory modeling, we found two distinct classes of individuals exhibiting each of these co-occurring symptom patterns: one class exhibited fairly low symptoms across time, and one class with elevated symptoms with varied fluctuation across time (ADHD symptoms starting high but decreasing, anxiety symptoms high and stable, and depressive symptoms fluctuating but peaking at clinically significant levels in young adulthood). All high trajectory classes were associated with age 9 adaptive skills; verbal IQ predicted higher anxiety and depressive symptom classes. After accounting for verbal IQ, all high symptom trajectory classes were negative predictors of objective adult outcomes. These findings call for wide-ranging considerations of the needs of individuals across ability levels, autism symptoms, and behavioral and emotional challenges.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderAutistic DisorderAdolescentAdultAnxiety DisordersChildChild, PreschoolHumansPsychopathologyYoung Adultautismco-occurring symptomsdevelopmentlongitudinal dataoutcomestrajectories

Identifiers

PMID32677592
PMCPMC7655668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.