ArticleGlobal spine journal2020
Sensitivity and Specificity of Gene Xpert in the Diagnosis of Spinal Tuberculosis: A Prospective Controlled Clinical Study.
Article in Global spine journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of GeneXpert in the diagnosis of spinal tuberculosis: A systematic review and meta-analysis.Narra J · 2024Pooled it
- Efficacy of Xpert in tuberculosis diagnosis based on various specimens: a systematic review and meta-analysis.Frontiers in cellular and infection microbiology · 2023Pooled it
- Rapid Molecular Diagnostics for MDR Nosocomial Infections in ICUs: Integration with Prevention, Stewardship, and Novel Therapies.Diagnostics (Basel, Switzerland) · 2025Review
- Spinal tuberculosis treatment duration: Correlating MRI findings with therapeutic outcomes.GMS hygiene and infection control · 2025Article
- Xpert MTB/RIF Ultra Ct Value: A Quick Indicator of Sputum Bacillary Load and Smear Status Prediction in Individuals with Pulmonary Tuberculosis.The East African health research journal · 2025Article
- Surgery for deformities in pediatric spinal tuberculosis: single centre review of 51 cases.Spine deformity · 2025Article
- A Comparison Study of Lymph Node Tuberculosis and Sarcoidosis Involvement to Facilitate Differential Diagnosis and to Establish a Predictive Score for Tuberculosis.Pathogens (Basel, Switzerland) · 2024Article
- Tuberculosis of the spine.World journal of orthopedics · 2023Review
- The value of histopathology combined with CapitalBioFrontiers in medicine · 2023Article
- Intestinal tuberculosis masquerading as carcinoma colon: a case report of diagnostic quandary in low-resource setting.Journal of surgical case reports · 2022Article
- Performance Comparison of GeneXpert MTB/RIF, Gene Chip Technology, and Modified Roche Culture Method in DetectingContrast media & molecular imaging · 2022Article
- Clinico-Radio-Histopathological Correlation by C-Arm Image-Guided Biopsy in Spinal Tuberculosis.Indian journal of orthopaedics · 2021Article
- Central nervous system tuberculosis.Current opinion in neurology · 2021Review
- Gene Xpert/MTB RIF assay for spinal tuberculosis- sensitivity, specificity and clinical utility.Journal of clinical orthopaedics and trauma · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designProspective matched cohort study.
objectiveTo evaluate the sensitivity and specificity of Gene Xpert in the diagnosis of spinal tuberculosis.
methodsFrom January 2016 to August 2018, Gene Xpert results were prospectively studied in 68 patients of clinicoradiologically suspected spinal tuberculosis (STB) and a control group (CG) of 92 patients, all of whom underwent computed tomography-guided/C-arm-guided/open surgical biopsy. Sensitivity, specificity, positive predictive value, and negative predictive value are obtained using standard equations.
resultsOut of 68 cases of STB, Gene Xpert was positive in 62 (true positive: 62/68) and negative in 6 (false negative: 6/68). Gene Xpert was negative for all 92 cases of CG (true negative: 92/92, false positive 0/92). Thus, in our series, sensitivity of Gene Xpert is 91.18%, specificity is 100%, positive predictive value is 100%, and negative predictive value is 93.88%. Out of all cases of STB, 62/68 (91.18%) were Gene Xpert positive, but only 35/64 (54.69%) was acid-fast bacilli (AFB) culture positive and 53/60(88.33%) was histopathologically conclusive of TB. Also, Gene Xpert was positive in 7/7 (100%) cases of STB in which histopathology were inconclusive and 25/29 (86.21%) cases of STB in which AFB culture was negative.
conclusionIn STB, Gene Xpert clearly outperforms AFB culture and histopathology due to its high sensitivity and specificity apart from being rapid in diagnosis. Hence it is justified to diagnose spinal tuberculosis by Gene Xpert though histopathology is confirmative and AFB culture remains the gold standard.
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