Evidence map›Paper›PMID 32677363›Full record

ArticleJournal of cachexia, sarcopenia and muscle2020

Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness.

Paul R Kemp, Richard Paul, Aaron C Hinken, David Neil, Alan Russell, Mark J Griffiths

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05456997 (Prospective Observational Study of Metabolic Myopathy in Cushing's Syndrome or Pheochromocytoma Patients Undergoing Adrenalectomy), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05456997 terminatednot on this mapstarted 2023, after this paper: background citation

Prospective Observational Study of Metabolic Myopathy in Cushing's Syndrome or Pheochromocytoma Patients Undergoing Adrenalectomy

TypeobservationalSponsorBarts & The London NHS TrustRan2023 to 2023Enrolled1ConditionsCushing Syndrome, Pheochromocytoma, Conns Syndrome, Metabolic MyopathyArmsMuscle biopsy
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Circulating biomarkers in older adults with and without sarcopenia: a systematic review and meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Paul R KempCardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.ORCID 0000-0001-8975-7293
Richard PaulCardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.
Aaron C HinkenMuscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Inc, Collegeville, PA, USA.
David NeilMuscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Inc, Collegeville, PA, USA.
Alan RussellMuscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Inc, Collegeville, PA, USA.
Mark J GriffithsCardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.
GlaxoSmithKline (United States) · USLung Institute · USGuy's and St Thomas' NHS Foundation Trust · GB

Funding

Department of Health
6 · The paper itself

Abstract

backgroundSurgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little, and is likely to be accompanied by marked changes in circulating metabolites and proteins. Determining these changes may help understand the variability and identify novel therapeutic approaches or markers of muscle wasting.

methodsTo determine the association between muscle loss and circulating metabolites, we studied 20 male patients (median age, 70.5, interquartile range, 62.5-75) undergoing aortic surgery. Muscle mass was determined before and 7 days after surgery and blood samples were taken before surgery, and 1, 3, and 7 days after surgery. The circulating metabolome and proteome were determined using commercial services (Metabolon and SomaLogic).

resultsTen patients lost more than 10% of the cross-sectional area of the rectus femoris (RF

conclusionsWe show that pre-existing mitochondrial dysfunction and reduced cortisol inactivation contribute to muscle loss following surgery. The data also implicate GDF-15 and IL-15RA in mitochondrial dysfunction.

Indexed as

Hand StrengthMitochondriaVentricular Function, LeftAgedHumansIntensive Care UnitsMaleMiddle AgedQuadriceps MuscleStroke VolumeAortic surgeryCortisolMetabolomicsMitochondrial dysfunctionMuscle wasting

Identifiers

PMID32677363
PMCPMC7567140
OpenAlexW3043566896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.