Evidence map›Paper›PMID 32677343›Full record

ArticleAmerican journal of medical genetics. Part A2020

Ocular measurements in fetal alcohol spectrum disorders.

Diego A Gomez, Philip A May, Barbara G Tabachnick, Julie M Hasken, Elizabeth R Lyden, Wendy O Kalberg, H Eugene Hoyme, Melanie A Manning, Margaret P Adam, Luther K Robinson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 1 country.

Diego A GomezCollege of Arts and Sciences, Creighton University, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0001-7818-3546
Philip A MayDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Barbara G TabachnickDepartment of Psychology, California State University, Northridge, California, USA.
Julie M HaskenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Elizabeth R LydenDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Wendy O KalbergCenter on Alcoholism, Substance Abuse, & Addictions, University of New Mexico, Albuquerque, New Mexico, USA.
H Eugene HoymeDepartment of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona, USA.
Melanie A ManningDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Margaret P AdamDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Luther K RobinsonDepartment of Pediatrics, State University of New York, Buffalo, New York, USA.
Kenneth Lyons JonesDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA.
David BuckleyCenter on Alcoholism, Substance Abuse, & Addictions, University of New Mexico, Albuquerque, New Mexico, USA.
Omar A Abdul-RahmanDepartment of Genetic Medicine, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-1020-9989
University of New Mexico · USUniversity of North Carolina at Chapel Hill · USCalifornia State University, Northridge · USCreighton University · USNebraska Medical Center · USSanford Health · USStanford University · USUniversity at Buffalo, State University of New York · USUniversity of California San Diego · USUniversity of Nebraska Medical Center · USUniversity of Washington · US

Funding

Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal EpidemiologyR01AA015134 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2006 to 2022
$4.5M
NIAAA NIH HHS R01 AA015134NIAAA NIH HHS RO1/UO1 AA015134
6 · The paper itself

Abstract

Fetal alcohol spectrum disorders (FASD) describe a range of physical, behavioral, and neurologic deficits in individuals exposed to alcohol prenatally. Reduced palpebral fissure length is one of the cardinal facial features of FASD. However, other ocular measurements have not been studied extensively in FASD. Using the Fetal Alcohol Syndrome Epidemiologic Research (FASER) database, we investigated how inner canthal distance (ICD), interpupillary distance (IPD), and outer canthal distance (OCD) centiles differed between FASD and non-FASD individuals. We compared ocular measurement centiles in children with FASD to non-FASD individuals and observed reductions in all three centiles for ICD, IPD, and OCD. However, when our non-FASD children who had various forms of growth deficiency (microcephaly, short-stature, or underweight) were compared to controls, we did not observe a similar reduction in ocular measurements. This suggests that reductions in ocular measurements are a direct effect of alcohol on ocular development independent of its effect on growth parameters, which is consistent with animal models showing a negative effect of alcohol on developing neural crest cells. Interpupillary distance centile appeared to be the most significantly reduced ocular measure we evaluated, suggesting it may be a useful measure to be considered in the diagnosis of FASD.

Indexed as

Alcohol DrinkingAnimalsChildEyeFaceFemaleFetal Alcohol Spectrum DisordersHumansMaleMaternal-Fetal ExchangeMicrocephalyNeural CrestPregnancy

Identifiers

PMID32677343
PMCPMC12051940
OpenAlexW3043567842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.