ArticleThe Journal of comparative neurology2021
Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.
Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.Communications biology · 2026Article
- Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice.Molecular brain · 2026Article
- The cingulum: anatomy, connectivity and what goes beyond.Brain communications · 2025Review
- Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation.Nature communications · 2024Article
- Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuronal mechanism of innate rapid processing of threating animacy cue in primates: insights from the neuronal responses to snake images.Frontiers in psychology · 2024Review
- Empathy Modulates the Activity of the Sensorimotor Mirror Neuron System during Pain Observation.Behavioral sciences (Basel, Switzerland) · 2023Article
- Reduced cortical neuron number and neuron density in schizophrenia with focus on area 24: a post-mortem case-control study.European archives of psychiatry and clinical neuroscience · 2023Article
- Abstraction of Reward Context Facilitates Relative Reward Coding in Neural Populations of the Macaque Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cellular Diversity in Human Subgenual Anterior Cingulate and Dorsolateral Prefrontal Cortex by Single-Nucleus RNA-Sequencing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A proposed attention-based model for spatial memory formation and retrieval.Cognitive processing · 2023Review
- Subgenual and Hippocampal Pathways in Amygdala Are Set to Balance Affect and Context Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
- Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms.BMC psychiatry · 2022Article
- Neuronal activity in dorsal anterior cingulate cortex during economic choices under variable action costs.eLife · 2021Article
- The contributions of entorhinal cortex and hippocampus to error driven learning.Communications biology · 2021Article
- Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey.Frontiers in neural circuits · 2021Article
- Preferential Neuronal Responses to Snakes in the Monkey Medial Prefrontal Cortex Support an Evolutionary Origin for Ophidiophobia.Frontiers in behavioral neuroscience · 2021Article
- Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice.Molecular painArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The anterior cingulate cortex (ACC) is important for decision-making as it integrates motor plans with affective and contextual limbic information. Disruptions in these networks have been observed in depression, bipolar disorder, and post-traumatic stress disorder. Yet, overlap of limbic and motor connections within subdivisions of the ACC is not well understood. Hence, we administered a combination of retrograde and anterograde tracers into structures important for contextual memories (entorhinal cortex), affective processing (amygdala), and motor planning (dorsal premotor cortex) to assess overlap of labeled projection neurons from (outputs) and axon terminals to (inputs) the ACC of adult rhesus monkeys (Macaca mulatta). Our data show that entorhinal and dorsal premotor cortical (dPMC) connections are segregated across ventral (A25, A24a) and dorsal (A24b,c) subregions of the ACC, while amygdalar connections are more evenly distributed across subregions. Among all areas, the rostral ACC (A32) had the lowest relative density of connections with all three regions. In the ventral ACC, entorhinal and amygdalar connections strongly overlap across all layers, especially in A25. In the dorsal ACC, outputs to dPMC and the amygdala strongly overlap in deep layers. However, dPMC input to the dorsal ACC was densest in deep layers, while amygdalar inputs predominantly localized in upper layers. These connection patterns are consistent with diverse roles of the dorsal ACC in motor evaluation and the ventral ACC in affective and contextual memory. Further, distinct laminar circuits suggest unique interactions within specific ACC compartments that are likely important for the temporal integration of motor and limbic information during flexible goal-directed behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.