Evidence map›Paper›PMID 32676988›Full record

ArticleMolecular neurobiology2020

Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1

Chetan Singh Rajpurohit, Vivek Kumar, Arquimedes Cheffer, Danyllo Oliveira, Henning Ulrich, Oswaldo Keith Okamoto, Mayana Zatz, Uzair Ahmad Ansari, Vinay Kumar Khanna, Aditya Bhushan Pant

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  5. Aberrant evoked calcium signaling and nAChR cluster morphology in aFrontiers in cell and developmental biology · 2024
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  10. Genes · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Chetan Singh RajpurohitSystem Toxicology & Health Risk assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India.
Vivek KumarDepartment of Genetics and Evolutionary Biology, Human Genome and Stem-Cell Research Center, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
Arquimedes ChefferDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Danyllo OliveiraDepartment of Genetics and Evolutionary Biology, Human Genome and Stem-Cell Research Center, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
Henning UlrichDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Oswaldo Keith OkamotoDepartment of Genetics and Evolutionary Biology, Human Genome and Stem-Cell Research Center, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
Mayana ZatzDepartment of Genetics and Evolutionary Biology, Human Genome and Stem-Cell Research Center, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
Uzair Ahmad AnsariSystem Toxicology & Health Risk assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India.
Vinay Kumar KhannaSystem Toxicology & Health Risk assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India.
Aditya Bhushan PantSystem Toxicology & Health Risk assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India. abpant@iitr.res.in.ORCID http://orcid.org/0000-0002-7674-6242
Universidade de São Paulo · BRIndian Institute of Toxicology Research · INUniversity of Bonn · DE

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307611/2018-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 405243/2015-4Department of Biotechnology , Ministry of Science and Technology DBT/IC-2/Indo-Brazil/2016-19/02FINEP-CTC 0108057900Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/50880-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/02293Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/08028-1Instituto Nacional de Ciência e Tecnologia para o Controle das Intoxicações por Plantas 573633/2008-8
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with no cure. The reports showed the role of nearby astrocytes around the motor neurons as one among the causes of the disease. However, the exact mechanistic insights are not explored so far. Thus, in the present investigations, we employed the induced pluripotent stem cells (iPSCs) of Cu/Zn-SOD1

Indexed as

AutophagyAmyotrophic Lateral SclerosisApoptosisAstrocytesCell DifferentiationElectrophysiological PhenomenaGene Expression RegulationHumansInduced Pluripotent Stem CellsLysosomesMatrix MetalloproteinasesModels, BiologicalMotor NeuronsNeural Stem CellsOxidative StressReactive Oxygen SpeciesMatrix MetalloproteinasesReactive Oxygen SpeciesSuperoxide Dismutase-1Amyotrophic lateral sclerosisAstrocytesAutophagyConditioned mediumMotor neuron diseaseNon-cell autonomous neurotoxicitySOD1

Identifiers

PMID32676988
OpenAlexW3043168093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.