ArticleBiological trace element research2021
Factors Influencing Selenium Concentration in Community-Dwelling Patients with Type 2 Diabetes Mellitus.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Selenium-loaded sustained-release schizophyllan alleviates pancreatic and pulmonary inflammatory damage in type 1 diabetes mellitus by modulating gut microbiota and T cell balance.Journal of nanobiotechnology · 2026Article
- Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19-A Preventable Trigger for Autoimmune Disease.International journal of molecular sciences · 2021Review
- Characterization and Quantification of Selenoprotein P: Challenges to Mass Spectrometry.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Selenium (Se) plays an important role in the pathogenesis of diabetes, and which factors affecting Se concentration in patients with type 2 diabetes mellitus (T2DM) are unknown. This study aimed to explore the factors influencing Se concentration in community-dwelling individuals with T2DM. A total of 176 patients with T2DM were involved, and their general information was collected through a self-designed questionnaire. Venous blood samples and hair samples were collected to detect Se concentration and biochemical parameters. Multiple linear regression and binary logistic regression analysis were used to analyze the factors influencing Se concentration in patients with T2DM. The factors influencing selenoprotein P concentration in patients with T2DM included alkaline phosphatase (β = - 1.373; 95% CI: 0.087-0.736; P = 0.012), systolic blood pressure (SBP; β = - 0.047; 95% CI: 0.930-0.978; P < 0.001), the duration of T2DM (β = - 0.074; 95% CI: 0.877-0.983; P = 0.011), and clinical complications (β = 1.237; 95% CI: 1.465-8.109; P = 0.005). The factors influencing glutathione peroxidase activity in patients with T2DM were creatinine (CREA; β = - 0.378; P < 0.001), uric acid (β = - 0.069; P = 0.009), body mass index (β = - 2.177; P = 0.002), SBP (β = - 0.275; P = 0.031), and medical payment (β = 29.160; P < 0.001). The factors influencing serum Se concentration in patients with T2DM were albumin (β = - 1.391; 95% CI: 0.065-0.959; P = 0.043) and CREA (β = - 1.482; 95% CI: 0.072-0.718; P = 0.012). The factors influencing hair Se concentration in patients with T2DM were smoking (β = - 1.151; 95% CI: 0.133-0.755; P = 0.010), drinking (β = 1.366; 95% CI: 1.191-12.909; P = 0.025), and hair dyeing (β = - 1.113; 95% CI: 0.124-0.867; P = 0.025). In conclusion, the Se concentration in patients with T2DM was mainly affected by liver and renal function. When liver and/or renal function was impaired, the Se concentration in patients with T2DM was decreased.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.