Evidence map›Paper›PMID 32676917›Full record

ArticleActa parasitologica2021

Recombinant C-Reactive Protein: A Potential Candidate for the Treatment of Cutaneous Leishmaniasis of BALB/c Mice Caused by Leishmania major.

Seyedeh Noushin Zahedi, Seyed Hossein Hejazi, Maryam Boshtam, Farahnaz Amini, Hossein Fazeli, Mahdieh Sarmadi, Mahsa Rahimi, Hossein Khanahmad

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Article in Acta parasitologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Seyedeh Noushin ZahediDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Hezarjerib Street, 8174643446, Isfahan, Iran.
Seyed Hossein HejaziDepartment of Parasitology and Mycology, Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam BoshtamIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Farahnaz AminiFaculty of Medicine and Health Sciences, School of Healthy Aging, Medical Aesthetics and Regenerative Medicine, UCSI University, Kuala Lumpur, Malaysia.
Hossein FazeliDepartment of Bacteriology and Virology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahdieh SarmadiDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Hezarjerib Street, 8174643446, Isfahan, Iran.
Mahsa RahimiDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Hezarjerib Street, 8174643446, Isfahan, Iran.
Hossein KhanahmadDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Hezarjerib Street, 8174643446, Isfahan, Iran. h_khanahmad@med.mui.ac.ir.ORCID http://orcid.org/0000-0002-5573-3557
Isfahan University of Medical Sciences · IRUCSI University · MY

Funding

Isfahan University of Medical Sciences (IR) 397345
6 · The paper itself

Abstract

purposeLeishmaniasis, a widespread parasitic disease, is a public health concern that is endemic in more than 90 countries. Owing to the drug resistance and also undesirable complications, designing new therapeutic methods are essential. C-reactive protein (CRP) is an acute phase protein of plasma with several immune modulatory functions. This study aimed to evaluate the effect of human recombinant CRP (hrCRP) on treating cutaneous leishmaniasis in mice models.

methodshrCRP was expressed in E. coli Rosetta-gami and extracted from the SDS-PAGE gel. Male BALB/c mice were inoculated subcutaneously at the base of their tails by 1 × 10

resultsThe mean area of the lesions was decreased by about seven folds in the intervention group as compared to the control group after two weeks of the treatment (p = 0.024). The results were verified by the real-time polymerase chain reaction so that the parasite burden was determined 2

conclusionThe results indicate a potential therapeutic role for hrCRP in improving cutaneous leishmaniasis due to Leishmania major in mice models. The healing was in a stage-dependent manner.

Indexed as

Leishmania majorLeishmaniasis, CutaneousAnimalsC-Reactive ProteinEscherichia coliHumansMaleMiceMice, Inbred BALB CC-Reactive ProteinC-reactive proteinCutaneous leishmaniasisLeishmania majorRecombinant protein

Identifiers

PMID32676917
OpenAlexW3042515694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.