ArticleAnnals of intensive care2020
Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study.
Article in Annals of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05074758 (Characterization of the microVAScular Dysfunction in COvid-19 ARDS), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of the microVAScular Dysfunction in COvid-19 ARDS
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2022Pooled it
- COVID-19 associated pediatric vasculitis: A systematic review and detailed analysis of the pathogenesis.Seminars in arthritis and rheumatism · 2022Pooled it
- Incidence and prognostic value of pulmonary embolism in COVID-19: A systematic review and meta-analysis.PloS one · 2022Pooled it
- sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial.Scientific reports · 2025Trial
- Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells.Stem cell reviews and reports · 2021Trial
- Perioperative Coronavirus Disease 2019 Infection and Its Impact on Postoperative Outcomes: Pulmonary Complications and Mortality Based on Korean National Health Insurance Data.Journal of personalized medicine · 2025Article
- Determination of positive end-expiratory pressure in COVID-19-related acute respiratory distress syndrome: A systematic review.European journal of anaesthesiology and intensive care · 2024Article
- Identification and validation of respiratory subphenotypes in patients with COVID-19 acute respiratory distress syndrome undergoing prone position.Annals of intensive care · 2024Article
- Ventilatory Management of Patients with Acute Respiratory Distress Syndrome Due to SARS-CoV-2.Journal of clinical medicine · 2023Review
- Prone Positioning for Patients With COVID-19-Induced Acute Hypoxemic Respiratory Failure: Flipping the Script.Respiratory care · 2023Review
- Is COVID-19 different from other causes of acute respiratory distress syndrome?Journal of intensive medicine · 2023Review
- Physiologic dead space is independently associated with mortality and discharge of mechanically ventilated patients with COVID-19 ARDS: a retrospective study.Scientific reports · 2023Article
- Increased Circulating CD62EStem cell reviews and reports · 2023Article
- Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study.Respiratory research · 2022Article
- Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions.Intensive care medicine · 2022Review
- Early versus late intubation in COVID-19 patients failing helmet CPAP: A quantitative computed tomography study.Respiratory physiology & neurobiology · 2022Article
- Gas Exchange Mechanism of High Frequency Ventilation: A Brief Narrative Review and Prospect.Journal of Shanghai Jiaotong University (science) · 2022Article
- Potential for the lung recruitment and the risk of lung overdistension during 21 days of mechanical ventilation in patients with COVID-19 after noninvasive ventilation failure: the COVID-VENT observational trial.BMC anesthesiology · 2022Observational
- Does the intubation timeline affect the in-hospital mortality of COVID-19 patients? A retrospective cohort study.Frontiers in medicine · 2022Article
- Extracorporeal carbon dioxide removal with the Advanced Organ Support system in critically ill COVID-19 patients.Artificial organs · 2021Observational
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleCOVID-19 ARDS could differ from typical forms of the syndrome.
objectivePulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics.
methodsBetween March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1-4] day after intubation (median [IQR]). MEASUREMENTS AND MAIN
resultsThirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1-44.7] mL/cmH
conclusionsWe observed early in the course of COVID-19 ARDS high V
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