ArticleSurgical endoscopy2021
Is interval appendectomy really needed? A closer look at neoplasm rates in adult patients undergoing interval appendectomy after complicated appendicitis.
Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.Langenbeck's archives of surgery · 2023Pooled it
- The role of viruses in human acute appendicitis: a systematic literature review.International journal of colorectal disease · 2023Pooled it
- Revisiting Amyand's Hernia: A 20-Year Systematic Review.World journal of surgery · 2021Pooled it
- Successful interval laparoscopic appendectomy for walled-off perforated appendicitis during pregnancy: a case report.International journal of surgery case reports · 2026Article
- Global practices and attitudes in acute appendicitis management: the PAMAP-W international survey and Delphi consensus study on the WSES appendicitis grading system.World journal of emergency surgery : WJES · 2026Article
- True Incidence of Appendiceal Neoplasms in Patients Presenting with Complicated Appendicitis: A Call for a Revised Management Algorithm.Annals of surgical oncology · 2026Article
- The risk of neoplasms in appendiceal abscess: what emergency surgeons should know.Frontiers in oncology · 2026Review
- The Human Appendix and Antibiotics: Choice and Beneficence.ANZ journal of surgery · 2025Article
- Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract.World journal of gastrointestinal surgery · 2025Review
- Indication of conservative treatment by antibiotics for uncomplicated and complicated acute appendicitis.World journal of gastrointestinal surgery · 2024Article
- Early versus delayed appendicectomy for appendiceal phlegmon or abscess.The Cochrane database of systematic reviews · 2024Review
- Interval appendectomy as a safe and feasible treatment approach after conservative treatment for appendicitis with abscess: a retrospective, single-center cohort study.Updates in surgery · 2023Article
- Comparison of the risk of appendiceal tumors in uncomplicated and complicated appendicitis.Surgical endoscopy · 2022Article
- Decision-making changes for patients and medical personnel in the management of acute appendicitis during the COVID-19 pandemic.BMC emergency medicine · 2022Article
- Pelvic Health Assessment in Adult Females Following Pediatric Appendicitis: A Monocentric Retrospective Case-Control Study.Children (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe treatment algorithm for appendicitis is evolving, with recent interest in non-operative management. However, the safety of non-operative management for patients with complicated appendicitis has been questioned due to concern for increased risk of occult appendiceal neoplasm in this patient population. Our study aims to determine the rate of neoplasms discovered during interval appendectomy for patients with complicated appendicitis and determine the necessity of interval appendectomy.
methodsA retrospective chart review was conducted on interval appendectomies performed in adult patients for complicated appendicitis at our institution over a 9-year period. Interval appendectomy was defined as appendectomy delayed from initial presentation with appendicitis. Complicated appendicitis was defined as perforation, phlegmon, and/or abscess as seen on computed tomography at time of presentation.
resultsWe identified 402 patients who underwent interval appendectomy for complicated appendicitis. A total of 36 appendiceal neoplasms were discovered on final pathology with an overall neoplasm rate of 9%. Patients with an appendiceal neoplasm were significantly older (56.6 years vs 45.1 years, p < 0.01). No patients under the age of 30 had a neoplasm. The rate of appendiceal neoplasms in patients 30 years and older was 11%. The rate for patients 50 years and older was 16%. For patients 80 years and older, the rate of appendiceal neoplasm was 43%.
conclusionThe risk of occult appendiceal neoplasm is low in patients under the age of 30; however, there was an 11% rate of appendiceal neoplasm in patients 30 years and older. The risk increases with increased age, with a 16% risk in patients 50 years and older. Given these findings, we recommend consideration of interval appendectomy in all patients 30 years and older with complicated appendicitis.
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