Evidence map›Paper›PMID 32676593›Full record

ArticlebioRxiv : the preprint server for biology2020

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2.

Sandra C A Nielsen, Fan Yang, Katherine J L Jackson, Ramona A Hoh, Katharina Röltgen, Bryan Stevens, Ji-Yeun Lee, Arjun Rustagi, Angela J Rogers, Abigail E Powell and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 21 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Sandra C A NielsenDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Fan YangDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Katherine J L JacksonGarvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Ramona A HohDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Katharina RöltgenDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Bryan StevensDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Ji-Yeun LeeDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Arjun RustagiDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA.
Angela J RogersDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
Abigail E PowellStanford ChEM-H and Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Javaria NajeebDepartment of Structural Biology, Stanford University, Stanford, CA 94305, USA.
Ana R Otrelo-CardosoDepartment of Structural Biology, Stanford University, Stanford, CA 94305, USA.
Kathryn E YostCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
Bence DanielDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Theodore S JardetzkyDepartment of Structural Biology, Stanford University, Stanford, CA 94305, USA.
Peter S KimStanford ChEM-H and Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Taia T WangDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA.
Benjamin A PinskyDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Catherine A BlishDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA.
Scott D BoydDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Stanford University · USChan Zuckerberg Initiative (United States) · USGarvan Institute of Medical Research · AUHoward Hughes Medical Institute · US

Funding

Understanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI RAVETCH, JEFFREY VICTOR · 2014 to 2023
$26.0M
Center for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8M
EMERGING INFECTIOUS DISEASEST32AI007502 · NIAID · STANFORD UNIVERSITY · PI Prasanna Jagannathan, DAVID A. RELMAN · 1995 to 2026
$6.8M
Effects of aging on primary and secondary vaccine responses in a 15-year longitudinal cohortR01AI130398 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2021
$4.0M
Regulation of the IgG Fc domain repertoireR01AI139119 · NIAID · STANFORD UNIVERSITY · PI WANG, TAIA · 2019 to 2023
$2.8M
Storage and recall of human B cell memory of influenza over tissues and timeR01AI127877 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2021
$2.0M
Metabolic derangements in ARDSK23HL125663 · NHLBI · STANFORD UNIVERSITY · PI ROGERS, ANGELA J · 2015 to 2018
$744k
Single cell epigenomics in cancer immunity and immunotherapyK08CA230188 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2018 to 2020
$448k
NCI NIH HHS K08 CA230188NHGRI NIH HHS RM1 HG007735NHLBI NIH HHS K23 HL125663NIAID NIH HHS R01 AI127877NIAID NIH HHS R01 AI130398NIAID NIH HHS R01 AI139119NIAID NIH HHS T32 AI007502NIAID NIH HHS U19 AI111825
6 · The paper itself

Abstract

During virus infection B cells are critical for the production of antibodies and protective immunity. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify extensive convergence of antibody sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.

Identifiers

PMID32676593
PMCPMC7359515
OpenAlexW3042013243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.