Evidence map›Paper›PMID 32676502›Full record

ArticleFrontiers in cell and developmental biology2020

Contribution of NAADP to Glutamate-Evoked Changes in Ca

Julia Hermann, Melanie Bender, Dagmar Schumacher, Marcel S Woo, Artem Shaposhnykov, Sina C Rosenkranz, Vladimir Kuryshev, Chris Meier, Andreas H Guse, Manuel A Friese and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Advances in Drug Discovery Targeting Lysosomal Membrane Proteins.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  6. NAADP-Evoked CaHandbook of experimental pharmacology · 2023
    Article
  7. NAADP-Mediated CaHandbook of experimental pharmacology · 2023
    Article
  8. Two-pore channels: going with the flows.Biochemical Society transactions · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Julia HermannInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Melanie BenderInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Dagmar SchumacherInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Marcel S WooInstitut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Artem ShaposhnykovInstitut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Sina C RosenkranzInstitut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Vladimir KuryshevInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Chris MeierOrganic Chemistry, Department of Chemistry, University of Hamburg, Hamburg, Germany.
Andreas H GuseThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Manuel A FrieseInstitut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Marc FreichelInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Volodymyr TsvilovskyyInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Heidelberg University · DEUniversität Hamburg · DEGerman Centre for Cardiovascular Research · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such as TRPML1, the (structurally) related Two Pore Channel type 1 (TPC1) and TPC2 channels as well as Ryanodine Receptors type 1 (RYR1; Guse, 2012). NAADP evokes calcium release from acidic calcium stores of many cell types (Guse, 2012), and NAADP-sensitive Ca

Indexed as

Ca2+ homeostasisglutamatehippocampal neuronsNAADPneuronal excitotoxicity

Identifiers

PMID32676502
PMCPMC7333232
OpenAlexW3036869880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.