ArticleQuantitative imaging in medicine and surgery2020
The association of myelination in the internal capsule with iron deposition in the basal ganglia in macaques: a magnetic resonance imaging study.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Sub-Networks of the Brain RHuman brain mapping · 2026Article
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Comparison of three magnetic resonance imaging measures of brain iron in healthy and cocaine use disorder participants.NMR in biomedicine · 2024Article
- Deep gray matters iron deposition is positively associated with white matter hyperintensity in hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Altered functional connectivity density and structural covariance networks in women with premenstrual syndrome.Quantitative imaging in medicine and surgery · 2023Article
- Early differentiation of neurodegenerative diseases using the novel QSM technique: what is the biomarker of each disorder?BMC neuroscience · 2022Review
- Brain pathological changes during neurodegenerative diseases and their identification methods: How does QSM perform in detecting this process?Insights into imaging · 2022Review
- Altered structural covariance and functional connectivity of the insula in patients with Crohn's disease.Quantitative imaging in medicine and surgery · 2022Article
- Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging.NeuroImage · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron plays a vital role in myelin synthesis and maintenance. A tight association between iron concentration and myelin content has been demonstrated in local brain regions; however, whether such a relationship exists between distant brain regions that are anatomically connected is largely unknown.
methodsWe conducted an
resultsSpearman's correlation analysis revealed a moderate to high (r=0.528-0.808, P<0.05) positive correlation between the magnetic susceptibility of the BG and the MWF of anatomically connected IC structures during myelin production and maintenance, but little significant correlation was found between the susceptibility of the BG and the MWF of WM structures not anatomically connected to the BG.
conclusionsThese results advance the understanding of the relationship between iron and myelin, and suggest that future studies should consider the impact that iron concentration in the BG has on the myelination of WM structures that are anatomically connected to the BG.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.