Evidence map›Paper›PMID 32676354›Full record

ReviewTranslational lung cancer research2020

Lung cancer biomarker testing: perspective from Europe.

Erik Thunnissen, Birgit Weynand, Dalma Udovicic-Gagula, Luka Brcic, Malgorzata Szolkowska, Paul Hofman, Silvana Smojver-Ježek, Sisko Anttila, Fiorella Calabrese, Izidor Kern and 11 more

Open access · diamondAbstract readReview
In one paragraph

Review in Translational lung cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Canadian Consensus Recommendations on the Management ofCurrent oncology (Toronto, Ont.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 14 countries.

Erik ThunnissenDepartment of Pathology, AmsterdamUMC, Location VU Medical Center, Amsterdam, The Netherlands.
Birgit WeynandPathology Department, Herestraat, Leuven, Belgium.
Dalma Udovicic-GagulaClinical Center University of Sarajevo, Department of Pathology and Cytology, Sarajevo, Bosnia and Herzegovina.
Luka BrcicDiagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Malgorzata SzolkowskaNational Tuberculosis and Lung Diseases Research Institute, Department of Pathology, Warsaw, Poland.
Paul HofmanNice University Hospital, FHU OncoAge, Laboratory of Clinical and Experimental Pathology, Nice, France.
Silvana Smojver-JežekClinical Unit for Pulmonary Cytology, Department of Pathology and Cytology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
Sisko AnttilaDepartment of Pathology, HUSLAB, Helsinki and Uusimaa Health Care District, Helsinki, Finland.
Fiorella CalabreseDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Izidor KernLaboratory for cytology and pathology, University Clinic Golnik, Golnik, Slovenia.
Birgit SkovDepartment of Pathology, University Hospital, Copenhagen Ø, Denmark.
Sven PernerInstitute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Vibeke G DaleDepartment of Pathology, St. Olavs Hospital, Trondheim, Norway.
Zivka EriInstitute for pulmonary diseases of Vojvodina, Department for Pathology, put dr Goldmana 4, Sremska Kamenica, Serbia.
Alex HaraganDepartment of Pathology, Royal Liverpool University Hospital, Liverpool, England.
Diana LeonteNational Institute of Pneumology, Pathology Department, Bucharest, Romania.
Lina CarvalloInstitute of Anatomical and Molecular Pathology, Faculty of Medicine - University of Coimbra, Coimbra, Portugal.
Spasenja Savic PrincePathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Siobhan NicholsonDepartment of Histopathology, St. James's Hospital, Dublin 8, Ireland.
Irene SansanoPathology Department, Passeig de la Vall d'Hebron 119-129, Barcelona, Spain.
Ales RyskaThe Fingerland Department of Pathology, Charles University Medical Faculty and University Hospital, Hradec Kralove, Czech Republic.
Amsterdam University Medical Centers · NLVlaams Patiëntenplatform · BEMedical University of Graz · ATUniversity Hospital Centre Zagreb · HRClinical Center University of Sarajevo · BAHospital District of Helsinki and Uusimaa · FISt. James's Hospital · IEUniversity Hospital of Basel · CHUniversity of Padua · ITUniversity of Sarajevo · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A questionnaire on biomarker testing previously used in central European countries was extended and distributed in Western and Central European countries to the pathologists participating at the Pulmonary Pathology Society meeting 26-28 June 2019 in Dubrovnik, Croatia. Each country was represented by one responder. For recent biomarkers the availability and reimbursement of diagnoses of molecular alterations in non-small cell lung carcinoma varies widely between different, also western European, countries. Reimbursement of such assessments varies widely between unavailability and payments by the health care system or even pharmaceutical companies. The support for testing from alternative sources, such as the pharmaceutical industry, is no doubt partly compensating for the lack of public health system support, but it is not a viable or long-term solution. Ideally, a structured access to testing and reimbursement should be the aim in order to provide patients with appropriate therapeutic options. As biomarker enabled therapies deliver a 50% better probability of outcome success, improved and unbiased reimbursement remains a major challenge for the future.

Indexed as

Europehealth careLung cancerpredictive testingtherapy

Identifiers

PMID32676354
PMCPMC7354119
OpenAlexW3034297016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.