ArticlePeerJ2020
Association of retinal nerve fiber abnormalities with serum CNTF and cognitive functions in schizophrenia patients.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography.Molecular psychiatry · 2024Pooled it
- Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Cognitive Physiology in Healthy Young Adults: Links to Ciliary Neurotrophic Factor and Retinal Biomarkers.Diagnostics (Basel, Switzerland) · 2026Article
- Special Issue: Does latent Toxoplasma infection mimic the immune profile of schizophrenia? Sex-specific cytokine and brain-marker alterations suggest partial overlap.Folia parasitologica · 2026Article
- Investigation of Retinal Biomarkers in Adult ADHD: A Comparative Optical Coherence Tomography Study.Noro psikiyatri arsivi · 2026Article
- Thinning of central foveal thickness in the retina of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review.Neuropsychobiology · 2025Article
- Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.Frontiers in medicine · 2025Review
- Retinal abnormalities and their relationship with social cognition in patients with schizophrenia and their healthy siblings.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2024Article
- Retinal Nerve Fiber Layer Thickness in Patients with Schizophrenia and Its Relation with Cognitive Impairment.Indian journal of psychological medicine · 2024Article
- Molecular physiology unlocks the mystery that relates cognitive impairment with the retina in schizophrenia and autism spectrum disorders: a perspective review.Frontiers in psychiatry · 2024Article
- Optical Coherence Tomography in Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.Biological psychiatry global open science · 2024Article
- Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.Circulation. Genomic and precision medicine · 2023Article
- Investigation of the Relationship Between Cognitive Functions and Retinal Findings From Spectral Optical Coherence Tomography in Patients With Schizophrenia and Their Healthy Siblings.Psychiatry investigation · 2023Article
- Differentiation of the retinal morphology aging trajectories in schizophrenia and their associations with cognitive dysfunctions.Frontiers in psychiatry · 2023Article
- Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions.Schizophrenia bulletin · 2022Article
- Relationships Among Retinal Nerve Fiber Layer Thickness, Vascular Endothelial Growth Factor, and Cognitive Impairment in Patients with Schizophrenia.Neuropsychiatric disease and treatment · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have reported reductions in retinal nerve fiber layers (RNFL) in schizophrenia. Ciliary neurotrophic factor (CNTF) has shown protective effects on both the neurogenesis and retina. This study aimed at investigating retinal abnormalities and establishing their correlation with serum CNTF and cognitive impairments in schizophrenic Chinese patients.
methodsIn total, 221 patients diagnosed with schizophrenia and 149 healthy controls were enrolled. Serum CNTF and clinical features of patients were investigated. Cognitive functions were evaluated with Repeatable Battery for the Assessment of Neuropsychology Status (RBANS). RNFL thickness and macular thickness (MT) of both eyes were measured with optical coherence tomography (OCT). T-tests and analysis of covariance were used to compare the variables between the patient and control groups, while multiple linear regression analysis was performed to determine the associations of RNFL thickness, CNTF and cognitive impairments.
resultsRNFL was found thinner in patients than in healthy controls (right: 88.18 ± 25.84 µm vs.102.13 ± 14.32 µm,
conclusionDecline in RNFL thickness was associated with cognitive impairments of schizophrenia and CNFT serum concentration. The possibility of reduction in RNFL thickness as a biomarker for schizophrenia needs to be further examined.
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