ReviewJournal of aging research2020
Frailty and the Risk of Polypharmacy in the Older Person: Enabling and Preventative Approaches.
Review in Journal of aging research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- SGLT2 Inhibitors in Older Adults With Cardiovascular Disease: A Systematic Review and Meta-Analysis.Journal of the American Geriatrics Society · 2025Pooled it
- Inflammatory Activities in Type 2 Diabetes Patients With Co-morbid Angiopathies and Exploring Beneficial Interventions: A Systematic Review.Frontiers in public health · 2020Pooled it
- Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial.BMC medicine · 2025Trial
- The association between polypharmacy, frailty and disability-free survival in community-dwelling healthy older individuals.Archives of gerontology and geriatricsTrial
- Ten tips to reduce fracture risk by non-pharmacologic interventions in CKD-associated osteoporosis.Clinical kidney journal · 2026Review
- Healthcare professionals' knowledge, attitude, and practice towards deprescribing in Gondar City, Ethiopia: a cross-sectional study.BMJ open · 2026Article
- The association between the degree of frailty and the risk of hospital related adverse events in older acutely admitted patients.Age and ageing · 2026Observational
- Association Between Polypharmacy and Socioeconomic and Demographic Factors in Adults Aged 50 Years and Older by Brazilian Macroregions.Pharmacoepidemiology and drug safety · 2026Article
- Use of medications with pharmacogenomic guidelines and adverse outcomes in hospitalised older patients: a retrospective cross-sectional study.The pharmacogenomics journal · 2026Article
- Prevalence and determinants of social frailty among community-dwelling empty-nest older adults in China.Frontiers in public health · 2026Article
- Article
- An automation framework for clinical codelist development validated with UK data from patients with multiple long-term conditions.BMC medical research methodology · 2025Article
- The symptom network of oral health conditions in older populations with oral frailty: a cross-sectional study.BMC oral health · 2025Article
- Preliminary results of a multidimensional approach to screen for frailty in community-dwelling older adults of eight Italian regions: the SUNFRAIL+ study.Frontiers in public health · 2025Article
- Development and validation of an electronic frailty index in a national health maintenance organization.Aging · 2024Article
- Identification and prediction of frailty among community-dwelling older Japanese adults based on Bayesian network analysis: a cross-sectional and longitudinal study.BMC public health · 2024Article
- Investigating the relationship between FRailty And Quality of LIfe in patients with heart faiLure and CKD (FRAIL study).ESC heart failure · 2024Article
- Cultural adaptation and validation of the Sinhala version of the Frail Non-disabled tool (FiND).BMC geriatrics · 2024Article
- Falls in hospitalized older adults and the use of fall risk-increasing drugs and anticholinergic medications in Colombia: a case‒control study.Frontiers in pharmacology · 2024Article
- Medication Assessment in an Older Population during Acute Care Hospitalization and Its Effect on the Anticholinergic Burden: A Prospective Cohort Study.International journal of environmental research and public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frail older people have an inherent risk of polypharmacy due to the need to treat multiple comorbidities, thus leading to various negative effects on their health due to the adverse actions from the drugs. This issue was discussed from a person-centered perspective, highlighting the category of frail older adults who are at a higher risk. Appropriate medication reconciliation in this population with useful prescribing tools (Beers and START/STOPP criteria) to minimize polypharmacy and to provide alternative prescriptive intervention could go alongside primary care to reduce the extent of frailty and polypharmacy. Reducing delayed referrals and extended hospitalization with electronic health record systems and using the signs of frailty from the Electronic Frailty Index (EFI) to predict polypharmacy for frail older persons are preventative approaches that proactively respond to frailty associated with the risk of polypharmacy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.