Evidence map›Paper›PMID 32676166›Full record

ArticleOncotarget2020

TAF15 contributes to the radiation-inducible stress response in cancer.

Abhay Kumar Singh, Vaishali Kapoor, Dinesh Thotala, Dennis E Hallahan

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  12. Liquid-liquid phase separation in tumor biology.Signal transduction and targeted therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Abhay Kumar SinghDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
Vaishali KapoorDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
Dinesh ThotalaDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
Dennis E HallahanDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
THE ROLE OF PROTEIN PHOSPHATASE PP2A IN RADIATION INDUCED STEM CELL APOPTOSISR01CA174966 · NCI · WASHINGTON UNIVERSITY · PI HALLAHAN, DENNIS E, SHARMA, GIRDHAR GOPAL · 2013 to 2017
$2.3M
Lysophospholipids in Radiation Induced Signal Transduction in Malignant GliomasR01CA140220 · NCI · WASHINGTON UNIVERSITY · PI HALLAHAN, DENNIS E · 2010 to 2014
$1.7M
IMAGE GUIDED IMMUNO THERAPY FOR INDUCIBLE ANTIGENSR21CA170169 · NCI · WASHINGTON UNIVERSITY · PI HALLAHAN, DENNIS E · 2012 to 2012
$200k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA140220NCI NIH HHS R01 CA174966NCI NIH HHS R21 CA170169
6 · The paper itself

Abstract

Resistance to radiation therapy is a significant problem in the treatment of non-small cell lung cancer (NSCLC). There is an unmet need to discover new molecular targets for drug development in combination with standard of care cancer therapy. We found that TAF15 was radiation-inducible using phage-displayed peptide libraries. In this study, we report that overexpression of TAF15 is correlated with worsened survival in NSCLC patients. Radiation treatment led to surface induction of TAF15

Indexed as

antibodylung cancerradiation inducibleTAF15

Identifiers

PMID32676166
PMCPMC7343639
OpenAlexW3041535953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.