Evidence map›Paper›PMID 32676149›Full record

ArticleACS medicinal chemistry letters2020

Designing Dihydrofolate Reductase Inhibitors as X-ray Radiosensitizers to Reverse Radioresistance of Cervical Cancer.

Yuanwei Liang, Delong Zeng, Yuanyuan You, Bin Ma, Xiaoling Li, Tianfeng Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuanwei LiangThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou 510632, China.
Delong ZengThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou 510632, China.
Yuanyuan YouThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou 510632, China.
Bin MaThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou 510632, China.
Xiaoling LiThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou 510632, China.
Tianfeng ChenThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou 510632, China.
First Affiliated Hospital of Jinan University · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-ray radiotherapy has been widely used in the treatment of cervical cancer, a common gynecologic malignant tumor. However, the therapeutic efficacy tends to be indistinctive. One major reason for this is amplification of the dihydrofolate reductase (DHFR) gene, which causes an increase in DHFR activity and attenuation of the treatment effect. To solve this problem, we synthesized a series of DHFR inhibitors derived from methotrexate (MTX) analogues as radiotherapy sensitizers. Activity screening revealed that compound

Identifiers

PMID32676149
PMCPMC7357216
OpenAlexW3036305030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.