Trial reportPain research & management2020
Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial.
Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled TrialEquivalence Trial
In one paragraph
Trial report in Pain research & management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04654845 (Patient Perception Between Two Emergency Treatments of Symptomatic Irreversible Pulpitis. A Randomized Multicenter Clinical Trial.), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patient Perception Between Two Emergency Treatments of Symptomatic Irreversible Pulpitis. A Randomized Multicenter Clinical Trial.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis.Biomedical engineering online · 2024Pooled it
- Effectiveness of mineral trioxide aggregate on postoperative pain in non-surgical endodontic treatment: a systematic review of randomized controlled trials.Evidence-based dentistry · 2024Pooled it
- The short-term postoperative pain and impact upon quality of life of pulpotomy and root canal treatment, in teeth with symptoms of irreversible pulpitis: A randomized controlled clinical trial.International endodontic journal · 2025Trial
- Outcomes of root canal therapy or full pulpotomy using two endodontic biomaterials in mature permanent teeth: a randomized controlled trial.Clinical oral investigations · 2022Trial
- Mineral Trioxide AggregateIranian endodontic journal · 2022Trial
- Anaesthetic Efficacy of 4% Articaine in Comparison with 2% Lidocaine as Intraligamentary Injections after an Ineffective Inferior Alveolar Nerve Block in Mandibular Molars with Irreversible Pulpitis: A Prospective Randomised Triple-Blind Clinical Trial.Pain research & management · 2021Trial
- A Conservative Restorative Protocol for Symptomatic Irreversible Pulpitis: Clinical Success and Rapid Pain Relief in a 27-Case Series with 36-Month Follow-Up.Dentistry journal · 2026Article
- Postoperative Pain and Matrix Metalloproteinase-9 Pulpal Blood Level in Symptomatic Pulpitis of Mature Molars Treated with Biodentine and Portland Cement Full Pulpotomy: A Randomized Clinical Trial.Journal of clinical and experimental dentistry · 2026Review
- Osteogenic Response of Saos-2 Cells to Calcium Silicate-based versus Hydroxyapatite-based Cements: A Comparative Study.Iranian endodontic journal · 2026Article
- Management of a Late Complication of Strip Perforation with Overextended Gutta-percha Using Intentional Replantation: A 10-Year Follow-up Case Report.Iranian endodontic journal · 2025Article
- Effect of Zinc Oxide Nanoparticles on Calcium-enriched Mixture Cement: Physical, Chemical, and Mechanical Properties.Iranian endodontic journal · 2025Article
- Partial Pulpectomy with Bio-Obturation for Internal Root Resorption: A Case Report.Iranian endodontic journal · 2025Article
- Non-Surgical Management of a Mandibular First Molar with Strip Perforation, Separated File, and Canal Ledge: A Case Report.Iranian endodontic journal · 2025Article
- Revascularization of an Immature Three Rooted First Mandibular Molar Using Concentrated Growth Factor: A Case Report.Iranian endodontic journal · 2025Article
- Conservative Management of Dens Invaginatus Type IIIb Using Photodynamic Therapy: A Case Report.Iranian endodontic journal · 2025Article
- Vital Pulp Therapy: Evidence-Based Techniques and Outcomes.Iranian endodontic journal · 2025Review
- Bio-obturation: A Novel Approach in Root Canal Treatment Using Endodontic Biomaterials.Iranian endodontic journal · 2025Article
- Micro-computed and cone beam-computed tomographies for identification of Canals' morphological patterns of mandibular canines in Egyptian and Saudi Subpopulations: A comparative study.The Saudi dental journal · 2024Article
- Comparative evaluation of various biomaterials as pulpotomy agents in molars with symptomatic irreversible pulpitis: A randomized single-blinded single-center control trial.Journal of conservative dentistry and endodontics · 2024Article
- Vital pulp therapy demystified.Journal of conservative dentistry and endodontics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 7 institutions in 1 country.
Mohammad Jafar EghbalIranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0003-0931-2118
Ali HaeriIranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.
Arash ShahravanEndodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.ORCID 0000-0001-5344-536X
Ali KazemiEndodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran.
Fariborz MoazamiEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.ORCID 0000-0002-3035-2926
Mohammad Ali MozayeniEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0003-0641-5218
Eshaghali SaberiEndodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
Mohammad SamieiEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.
Mehdi VatanpourEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.ORCID 0000-0002-8205-2087
Alireza Akbarzade BaghbanDepartment of Basic Sciences, Proteomics Research Center, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran 1616913111, Iran.ORCID 0000-0003-1026-4598
Mahta FazlyabEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.ORCID 0000-0003-0186-2908
Ardavan ParhizkarIranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0002-0712-2305
Mahboobe AhmadiEndodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.ORCID 0000-0002-2809-5334
Nazila Akbarian RadEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.
Shima BijariEndodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.ORCID 0000-0002-5701-5081
Delaram BineshmarvastiEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.ORCID 0000-0003-2302-5000
Paria DavoudiEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.ORCID 0000-0001-7137-2336
Roya DehghanEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.ORCID 0000-0002-0963-6289
Mandana DehghaniEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.ORCID 0000-0001-9427-4392
Habibollah EbrahimiEndodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
Nafiseh EmamiEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.ORCID 0000-0001-5772-1026
Nafiseh FarajianEndodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran.
Rahim FereidooniEndodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.ORCID 0000-0001-9602-1647
Gelareh GhobadiEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.
Mostafa GhodratiEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.ORCID 0000-0001-8963-6619
Atefeh GohariEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0001-6395-3616
Azadeh HashemiEndodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.ORCID 0000-0001-5960-7446
Mohammadreza HosseiniEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.
Elham KaramiEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.ORCID 0000-0002-6694-494X
Nasir KheirabadiEndodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.ORCID 0000-0003-4979-3980
Sepideh KozegariEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.
Hadi Labaf GhasemiEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.
Alireza MajidiEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.
Parastu MalekzadehEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.
Vahid MehrabiEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.
Mehrnush MohammadiEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.ORCID 0000-0001-9596-7414
Leila Moradi EslamiEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.
Atefeh NoghaniEndodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.
Negin OmataliEndodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.ORCID 0000-0002-1311-9321
Negar PourhatamiEndodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.ORCID 0000-0002-5358-6207
Behnam Rahbani NobarEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0003-1831-9557
Saeid RahmaniEndodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.ORCID 0000-0001-6716-8535
Parviz ShafaqEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.
Sara SoofiabadiEndodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.
Somaye TeimooriEndodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran.
Farzaneh VatandoostEndodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0002-8738-1437
Saeed AsgaryIranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.ORCID 0000-0001-6691-0478
Shahid Beheshti University of Medical Sciences · IRIslamic Azad University Dental Branch of Tehran · IRShiraz University · IRTabriz University of Medical Sciences · IRKerman University of Medical Sciences · IRZahedan University of Medical Sciences · IRShahed University · IR
Funding
No grant is acknowledged in the PubMed record.
Abstract
This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. In seven academic centers, 550 cariously exposed pulps were included and randomly allocated into PMTA (
Indexed as
AdultAluminum CompoundsCalcium CompoundsDental CementsDrug CombinationsFemaleHumansMaleMolarOxidesPostoperative PainPrevalencePulpotomyRoot Canal Filling MaterialsRoot Canal TherapySilicatesAluminum CompoundsCalcium CompoundsDental CementsDrug Combinationsmineral trioxide aggregateOxidesRoot Canal Filling MaterialsSilicates
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT04654845ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.