Evidence map›Paper›PMID 32675773›Full record

ArticleThe Pediatric infectious disease journal2020

Detection of Mycobacterium Tuberculosis DNA in Buccal Swab Samples from Children in Lima, Peru.

Juan A Flores, Roger Calderón, Annelies W Mesman, Martin Soto, Julia Coit, Juan Aliaga, Milagros Mendoza, Segundo R Leon, Kelika Konda, Francisco M Mestanza and 6 more

Abstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. High-sensitivity detection ofJournal of clinical microbiology · 2025
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  11. High-sensitivity detection ofmedRxiv : the preprint server for health sciences · 2024
    Article
  12. Article
  13. Article
  14. Tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid XpertmedRxiv : the preprint server for health sciences · 2023
    Article
  15. Review
  16. Article
  17. Oral Swab Specimens Tested With Xpert MTB/RIF Ultra Assay for Diagnosis of Pulmonary Tuberculosis in Children: A Diagnostic Accuracy Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juan A FloresFrom the Escuela de Tecnología Médica, Universidad Privada San Juan Bautista, Lima, Peru.
Roger CalderónSocios En Salud Sucursal Peru, Lima, Peru.
Annelies W MesmanDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
Martin SotoSocios En Salud Sucursal Peru, Lima, Peru.
Julia CoitDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
Juan AliagaFaculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Milagros MendozaSocios En Salud Sucursal Peru, Lima, Peru.
Segundo R LeonFrom the Escuela de Tecnología Médica, Universidad Privada San Juan Bautista, Lima, Peru.
Kelika KondaCentro de Investigación Interdisciplinaria en Sexualidad, Sida y Sociedad, Universidad Peruana Cayetano Heredia, Lima, Peru.
Francisco M MestanzaHospital Nacional Docente Madre Niño San Bartolomé, Ministerio de Salud del Peru, Lima, Peru.
Carlos J MendozaHospital Nacional Hipólito Unanue, Ministerio de Salud del Peru, Lima, Peru.
Leonid LeccaSocios En Salud Sucursal Peru, Lima, Peru.
Megan B MurrayDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
Rebecca C HolmbergAkonni Biosystems Inc, Frederick, Maryland.
Nira R PollockDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts.
Molly F FrankeDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.

Funding

Sequencing CoreU19AI109755 · NIAID · HARVARD MEDICAL SCHOOL · PI CHANDLER, DARRELL P, CULHANE, AEDIN C · 2014 to 2018
$29.1M
NIAID NIH HHS U19 AI109755
6 · The paper itself

Abstract

We examined Mycobacterium tuberculosis DNA detection from buccal swab samples collected from children in Lima, Peru. DNA was extracted and amplified via real-time polymerase chain reaction. Sensitivity was 21% (95% confidence interval [CI]: 7%-42%) in 24 culture-confirmed tuberculosis cases and 4.6% (95% CI: 1%-13%) in 65 clinically diagnosed unconfirmed cases. Sensitivity was highest for smear-positive tuberculosis. Specificity was 99% in the 199 controls (95% CI: 96%-100%).

Indexed as

AdolescentChildDNA, BacterialFemaleHumansMaleMouth MucosaMycobacterium tuberculosisPeruDNA, Bacterial

Identifiers

PMID32675773
PMCPMC7578116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.