Evidence map›Paper›PMID 32675297›Full record

ArticleOpen heart2020

Vitamin K for kidney transplant organ recipients: investigating vessel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial.

Jennifer Susan Lees, Kenneth Mangion, Elaine Rutherford, Miles D Witham, Rosemary Woodward, Giles Roditi, Tracey Hopkins, Katriona Brooksbank, Alan G Jardine, Patrick B Mark

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Cardiovascular magnetic resonance for the detection of descending thoracic aorta calcification in patients with end-stage renal disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jennifer Susan LeesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK jennifer.lees2@nhs.net.ORCID 0000-0001-6331-0178
Kenneth MangionInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Elaine RutherfordInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Miles D WithamAGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Rosemary WoodwardQueen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
Giles RoditiInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Tracey HopkinsQueen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
Katriona BrooksbankInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Alan G JardineInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Patrick B MarkInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
NHS Greater Glasgow and Clyde · GBUniversity of Glasgow · GBNIHR Newcastle Biomedical Research Centre · GB

Funding

British Heart Foundation PG/14/75/31083British Heart Foundation RE/13/5/30177
6 · The paper itself

Abstract

backgroundRenal transplant recipients (RTRs) exhibit increased vascular stiffness and calcification; these parameters are associated with increased cardiovascular risk. Activity of endogenous calcification inhibitors such as matrix gla protein (MGP) is dependent on vitamin K. RTRs commonly have subclinical vitamin K deficiency. The Vitamin K in kidney Transplant Organ Recipients: Investigating vEssel Stiffness (ViKTORIES) study assesses whether vitamin K supplementation reduces vascular stiffness and calcification in a diverse population of RTR. METHODS AND ANALYSIS: ViKTORIES (ISRCTN22012044) is a single-centre, phase II, parallel-group, randomised, double-blind, placebo-controlled trial of the effect of vitamin K supplementation in 90 prevalent RTR. Participants are eligible if they have a functioning renal transplant for DISCUSSION: This trial may identify a novel, inexpensive and low-risk treatment to improve surrogate markers of cardiovascular risk in RTR.

Indexed as

Dietary SupplementsKidney TransplantationAortic DiseasesClinical Trials, Phase II as TopicCoronary Artery DiseaseDouble-Blind MethodHumansRandomized Controlled Trials as TopicScotlandTime FactorsVascular CalcificationVascular StiffnessVitamin KmenadiolVitamin Kclinical trialsCT scanningMRIrenal diseaserisk factors

Identifiers

PMID32675297
PMCPMC7368482
OpenAlexW3038619697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.