Evidence map›Paper›PMID 32675206›Full record

ArticleThe European respiratory journal2020

Gene expression and

Jennifer A Aguiar, Benjamin J-M Tremblay, Michael J Mansfield, Owen Woody, Briallen Lobb, Arinjay Banerjee, Abiram Chandiramohan, Nicholas Tiessen, Quynh Cao, Anna Dvorkin-Gheva and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.

  1. Frontiers in immunology · 2021
    Pooled it
  2. Article
  3. Article
  4. Review
  5. A survey of SARS-CoV-2 tropism.Infectious diseases & immunity · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in allergy · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19.International journal of molecular sciences · 2024
    Review
  15. ADAM-17 Activity and Its Relation to ACE2: Implications for Severe COVID-19.International journal of molecular sciences · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 4 countries.

Jennifer A AguiarDept of Biology, University of Waterloo, Waterloo, ON, Canada.
Benjamin J-M TremblayDept of Biology, University of Waterloo, Waterloo, ON, Canada.
Michael J MansfieldGenomics and Regulatory Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Japan.
Owen WoodyFaculty of Mathematics, University of Waterloo, Waterloo, ON, Canada.
Briallen LobbDept of Biology, University of Waterloo, Waterloo, ON, Canada.ORCID 0000-0001-7921-0972
Arinjay BanerjeeMcMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.
Abiram ChandiramohanFirestone Institute for Respiratory Health - Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
Nicholas TiessenFirestone Institute for Respiratory Health - Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
Quynh CaoFirestone Institute for Respiratory Health - Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
Anna Dvorkin-GhevaMcMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-7295-7440
Spencer RevillFirestone Institute for Respiratory Health - Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
Matthew S MillerMcMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.
Christopher CarlstenDivision of Respiratory Medicine, Dept of Medicine, University of British Columbia, Vancouver, BC, Canada.
Louise OrganNottingham NIHR Biomedical Research Centre, Respiratory Research Unit, University of Nottingham, Nottingham, UK.
Chitra JosephNottingham NIHR Biomedical Research Centre, Respiratory Research Unit, University of Nottingham, Nottingham, UK.
Alison JohnNottingham NIHR Biomedical Research Centre, Respiratory Research Unit, University of Nottingham, Nottingham, UK.
Paul HansonCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Richard C AustinDivision of Nephrology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
Bruce M McManusCentre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Gisli JenkinsNottingham NIHR Biomedical Research Centre, Respiratory Research Unit, University of Nottingham, Nottingham, UK.
Karen MossmanMcMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-1725-5873
Kjetil AskMcMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-0202-735X
Andrew C DoxeyDept of Biology, University of Waterloo, Waterloo, ON, Canada.
Jeremy A HirotaDept of Biology, University of Waterloo, Waterloo, ON, Canada hirotaja@mcmaster.ca.
University of Waterloo · CAInstitute for Respiratory Health · AUMcMaster University · CAUniversity of Nottingham · GBUniversity of British Columbia · CAOkinawa Institute of Science and Technology Graduate University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the agent responsible for the 2003 SARS outbreak, utilises angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) host molecules for viral entry. ACE2 and TMPRSS2 have recently been implicated in SARS-CoV-2 viral infection. Additional host molecules including ADAM17, cathepsin L, CD147 and GRP78 may also function as receptors for SARS-CoV-2.To determine the expression and

Indexed as

Coronavirus InfectionsPandemicsPeptidyl-Dipeptidase APneumonia, ViralSerine EndopeptidasesAngiotensin-Converting Enzyme 2BetacoronavirusCOVID-19Endoplasmic Reticulum Chaperone BiPGene ExpressionGene Expression ProfilingHumansLungReceptors, VirusRespiratory MucosaSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Endoplasmic Reticulum Chaperone BiPHSPA5 protein, humanPeptidyl-Dipeptidase AReceptors, VirusSerine EndopeptidasesTMPRSS2 protein, human

Identifiers

PMID32675206
PMCPMC7366180
OpenAlexW3043649968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.