Evidence map›Paper›PMID 32675141›Full record

ArticleClinical medicine (London, England)2020

Guidance for the prevention and emergency management of adult patients with adrenal insufficiency.

Helen Simpson, Jeremy Tomlinson, John Wass, John Dean, Wiebke Arlt

Open access · diamondAbstract read
In one paragraph

Article in Clinical medicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Review
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  15. Review
  16. Adrenal insufficiency is common amongst kidney transplant recipients receiving maintenance prednisolone and can be predicted using morning cortisol.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  17. The essentials of acute oncology.Clinical medicine (London, England) · 2023
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  18. Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Helen SimpsonUniversity College London Hospitals NHS Foundation Trust, London, UK helen.simpson22@nhs.net.
Jeremy TomlinsonOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK.
John WassOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK.
John DeanRoyal College of Physicians, London, UK.
Wiebke ArltInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism · GBRoyal College of Physicians · GBUniversity College London · GBUniversity of Birmingham · GB

Funding

Medical Research Council MR/P011462/1
6 · The paper itself

Abstract

Adrenal insufficiency (AI) is an often-unrecognised endocrine disorder, which can lead to adrenal crisis and death if not identified and treated. Omission of steroids in patients with AI, particularly during physiological stress such as an intercurrent illness or surgery, can also lead to an adrenal crisis. The National Reporting and Learning System (NRLS) identified 78 incidents including two deaths and six incidents of severe harm to patients in a recent 4-year period. This guidance will go through causes of adrenal insufficiency, groups at risk of an adrenal crisis, emergency management and management for surgical procedures. A new NHS Steroid Emergency Card has been developed to be carried by patients at risk of adrenal crisis. We hope the new emergency card and this guidance will increase awareness of the need to start steroids promptly in patients at risk of an adrenal crisis, particularly those presenting in the emergency department or to acute medicine teams and those undergoing surgery or invasive procedures.

Indexed as

Adrenal InsufficiencyAcute DiseaseAdultEmergenciesEmergency Service, HospitalHumansSteroidsSteroidsadrenal crisisAdrenal insufficiencyemergency managementsteroids

Identifiers

PMID32675141
PMCPMC7385786
OpenAlexW3043068155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.