Evidence map›Paper›PMID 32675080›Full record

ArticleNeurology2020

Multitracer model for staging cortical amyloid deposition using PET imaging.

Lyduine E Collij, Fiona Heeman, Gemma Salvadó, Silvia Ingala, Daniele Altomare, Arno de Wilde, Elles Konijnenberg, Marieke van Buchem, Maqsood Yaqub, Pawel Markiewicz and 17 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 98 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. A unified model for staging amyloid and tau pathology in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026
    Article
  7. Article
  8. DynamicalbioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Review
  11. IRIS: Interpretable Risk Clustering Intelligence for Survival Analysis.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2025
    Article
  12. Potential utility of plasma pTau217 for assessing amyloid and tau biomarker profiles.European journal of nuclear medicine and molecular imaging · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan.European journal of nuclear medicine and molecular imaging · 2025
    Article
  18. Article
  19. Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025
    Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 2 institutions in 6 countries.

Lyduine E CollijFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Fiona HeemanFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0001-7769-8329
Gemma SalvadóFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Silvia IngalaFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Daniele AltomareFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Arno de WildeFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Elles KonijnenbergFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Marieke van BuchemFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Maqsood YaqubFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0003-2122-740X
Pawel MarkiewiczFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Sandeep S V GollaFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Viktor WottschelFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0002-2902-2268
Alle Meije WinkFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0002-8197-0118
Pieter Jelle VisserFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Charlotte E TeunissenFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Adriaan A LammertsmaFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Philip ScheltensFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0002-1046-6408
Wiesje M van der FlierFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0001-8766-6224
Ronald BoellaardFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Bart N M van BerckelFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
José Luis MolinuevoFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Juan Domingo GispertFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0002-6155-0642
Mark E SchmidtFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
Frederik BarkhofFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.ORCID 0000-0003-3543-3706
Isadora Lopes AlvesFrom Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium. i.lopesalves@amsterdamumc.nl.
ALFA Study, for the Alzheimer's Disease Neuroimaging Initiative
AMYPAD Consortium
University of Geneva · CHMACOM (United States) · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
CIHRDepartment of HealthNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS R01 AG043434NIA NIH HHS U01 AG024904NIBIB NIH HHS R01 EB009352
6 · The paper itself

Abstract

objectiveTo develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability.

methodsThree thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) from 6 cohorts (European Medical Information Framework for AD, Alzheimer's and Family, Alzheimer's Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3, Alzheimer's Disease Neuroimaging Initiative [ADNI]) who underwent amyloid PET were retrospectively included; 1,049 individuals had follow-up scans. With application of dataset-specific cutoffs to global standard uptake value ratio (SUVr) values from 27 regions, single-tracer and pooled multitracer regional rankings were constructed from the frequency of abnormality across 400 CU individuals (100 per tracer). The pooled multitracer ranking was used to create a staging model consisting of 4 clusters of regions because it displayed a high and consistent correlation with each single-tracer ranking. Relationships between amyloid stage, clinical variables, and longitudinal cognitive decline were investigated.

resultsSUVr abnormality was most frequently observed in cingulate, followed by orbitofrontal, precuneal, and insular cortices and then the associative, temporal, and occipital regions. Abnormal amyloid levels based on binary global SUVr classification were observed in 1.0%, 5.5%, 17.9%, 90.0%, and 100.0% of individuals in stage 0 to 4, respectively. Baseline stage predicted decline in Mini-Mental State Examination (MMSE) score (ADNI: n = 867,

conclusionThe pooled multitracer staging model successfully classified the level of amyloid burden in >3,000 individuals across cohorts and radiotracers and detects preglobal amyloid burden and distinct risk profiles of cognitive decline within globally amyloid-positive individuals.

Indexed as

Carbon RadioisotopesFluorine RadioisotopesAgedAlzheimer DiseaseAmyloidosisCerebral CortexCognitive DysfunctionCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedPositron-Emission TomographyCarbon RadioisotopesFluorine Radioisotopes

Identifiers

PMID32675080
PMCPMC7713745
OpenAlexW3042249111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.