Evidence map›Paper›PMID 32674988›Full record

ReviewTrends in microbiology2020

Human Organs-on-Chips for Virology.

Huaqi Tang, Yasmine Abouleila, Longlong Si, Ana Maria Ortega-Prieto, Christine L Mummery, Donald E Ingber, Alireza Mashaghi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Study Models forMicroorganisms · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. NAM journal · 2025
    Article
  12. Article
  13. Lung stem cells and respiratory epithelial chimerism in transplantation.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huaqi TangMedical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Yasmine AbouleilaMedical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Longlong SiWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Ana Maria Ortega-PrietoSection of Virology, Department of Medicine, Imperial College London, London, W2 1PG, UK.
Christine L MummeryDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZD, Leiden, The Netherlands.
Donald E IngberWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Vascular Biology Program and Department of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA.
Alireza MashaghiMedical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. Electronic address: a.mashaghi.tabari@lacdr.leidenuniv.nl.

Funding

Lung-on-a-Chip Disease Models for Efficacy Testing (COVID-19 Competitive Revision)UH3HL141797 · NHLBI · HARVARD UNIVERSITY · PI INGBER, DONALD E · 2019 to 2021
$5.2M
NHLBI NIH HHS UH3 HL141797
6 · The paper itself

Abstract

While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking. Human organ-on-a-chip (Organ Chip) microfluidic culture devices that recapitulate tissue-tissue interfaces, fluid flows, mechanical cues, and organ-level physiology have been developed to narrow the gap between in vitro experimental models and human pathophysiology. Here, we describe how recent developments in Organ Chips have enabled re-creation of complex pathophysiological features of human viral infections in vitro.

Indexed as

Virus Physiological PhenomenaAnimalsHumansMicrofluidicsOrgan Culture TechniquesVirologyVirus DiseasesVirusesmicrofluidicsmicrophysiological systemorgan-on-a-chipviral infectionsvirus

Identifiers

PMID32674988
PMCPMC7357975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.