Evidence map›Paper›PMID 32674971›Full record

ReviewSexual medicine2020

European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction.

Emmanuel Weyne, Marcus M Ilg, Onur Omer Cakir, Asif Muneer, Delphine Behr Roussel, Maarten Albersen, Javier Angulo, Giovanni Corona, Carlo Bettocchi, Yacov Reisman and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sexual medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 5 countries.

Emmanuel WeyneLaboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.
Marcus M IlgFaculty of Health, Education, Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, UK.
Onur Omer CakirDepartment of Urology, University College London Hospitals NHS Trust, London, UK; Division of Surgery and Interventional Science, UCL, London, UK.
Asif MuneerDepartment of Urology, University College London Hospitals NHS Trust, London, UK; Division of Surgery and Interventional Science, UCL, London, UK; NIHR Biomedical Research Centre University College London Hospitals, London, UK.
Delphine Behr RousselPelvipharm, Montigny-le-Bretonneux, France UMR1179, Université Versailles Saint Quentin en Yvelines, Montigny-le-Bretonneux, France.
Maarten AlbersenLaboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.
Javier AnguloServicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología (UFV-IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, Spain.
Giovanni CoronaEndocrinology Unit, Medical Department, Azienda USL, Maggiore-Bellaria Hospital, Bologna, Italy.
Carlo BettocchiDivision of Urology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Yacov ReismanFlare-Health, Amstelveen, The Netherlands.
Fabio CastiglioneDepartment of Urology, University College London Hospitals NHS Trust, London, UK; Division of Surgery and Interventional Science, UCL, London, UK; Unit of Urology, Division of Experimental Oncology, Urological Research Institute (URI), IRCCS Ospedale San Raffaele, Milan, Italy; Departement of Urology, Vita-Salute San Raffaele University, Milan, Italy. Electronic address: dr.castiglione.fabio@gmail.com.
Chelmsford and Essex Hospital · GBInstituto Ramón y Cajal de Investigación Sanitaria · ESKU Leuven · BEMedica (Italy) · ITOrgan Recovery Systems (Belgium) · BERadiotelevisione Italiana (Italy) · ITUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversity College London · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRodent animal models are currently the most used in vivo model in translational studies looking into the pathophysiology of erectile dysfunction after nerve-sparing radical prostatectomy.

aimThis European Society for Sexual Medicine (ESSM) statement aims to guide scientists toward utilization of the rodent model in an appropriate, timely, and proficient fashion.

methodsMEDLINE and EMBASE databases were searched for basic science studies, using a rodent animal model, looking into the consequence of pelvic nerve injury on erectile function.

main outcome measuresThe authors present a consensus on how to best perform experiments with this rodent model, the details of the technique, and highlight possible pitfalls.

resultsOwing to the specific issue-basic science-Oxford 2011 Levels of Evidence criteria cannot be applied. However, ESSM statements on this topic will be provided in which we summarize the ESSM position on various aspects of the model such as the use of the Animal Research Reporting In Vivo Experiments guideline and the of common range parameter for nerve stimulation. We also highlighted the translational limits of the model.

conclusionThe following statements were formulated as a suggestive guidance for scientists using the cavernous nerve injury model. With this, we hope to standardize and further improve the quality of research in this field. It must be noted that this model has its limitations. Weyne E, Ilg MM, Cakir OO, et al. European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction. Sex Med 2020;8:327-337.

Indexed as

Animal ModelCavernous NerveErectile DysfunctionRadical Prostatectomy

Identifiers

PMID32674971
PMCPMC7471127
OpenAlexW3042819260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.