Evidence map›Paper›PMID 32674529›Full record

ReviewClinical and molecular hepatology2020

Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH.

Theresa J Hydes, Sujan Ravi, Rohit Loomba, Meagan E Gray

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinical and molecular hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06664684 (Effects of Intermittent Fasting in Metabolic Dysfunction Associated Fatty Liver Disease), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06664684 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Intermittent Fasting in Metabolic Dysfunction Associated Fatty Liver Disease

TypeinterventionalSponsorIstanbul Bilgi UniversityRan2022 to 2023Enrolled55ConditionsIntermittent Fasting, Metabolic Dysfunction-Associated Fatty Liver DiseaseArmsEnergy-restricted dietary intervention, Energy + time-restricted dietary intervention
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Metabolic dysfunction-associated steatotic liver disease management in Saudi Arabia: A modified Delphi-based adaptation of international standards.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026
    Article
  10. Article
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  12. Review
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  14. Review
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  18. Machine learning uncovers manganese as a key nutrient associated with reduced risk of steatotic liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Theresa J HydesDivision of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sujan RaviDivision of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Rohit LoombaDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Meagan E GrayDivision of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
The Guts of HIV: Innate Immune Dysregulation as a Central Mechanism of Gastrointestinal and Liver Disease in HIV-1-infected IndividualsR01DK108353 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HEL, ZDENEK · 2015 to 2019
$1.6M
NCATS NIH HHS UL1 TR001442NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK108353NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and affects approximately one third of adults in the United States. The disease is becoming a global epidemic as a result of the rising rates of obesity and metabolic disease. Emerging data suggest weight loss of ≥10% overall body weight is beneficial in resolving steatosis and reversing fibrosis. Prospective trials comparing various diets are limited by lack of sufficient power as well as pre- and post-treatment histopathology, and therefore no specific diet is recommended at this time. In this narrative review we examine the pathophysiology behind specific macronutrient components that can either promote or reverse NAFLD to help inform more specific dietary recommendations. Overall, the data supports reducing saturated fat, refined carbohydrates, and red and processed meats in the diet, and increasing the consumption of plant-based foods. Diets that incorporate these recommendations include plant-based diets such as the Dietary Approaches to Stop Hypertension, Mediterranean, vegetarian, and vegan diets.

Indexed as

Non-alcoholic Fatty Liver DiseaseAdultDietHumansObesityProspective StudiesWeight LossDietDiet, HealthyDiet, VegetarianNonalcoholic fatty liver disease

Identifiers

PMID32674529
PMCPMC7641567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.