Evidence map›Paper›PMID 32674491›Full record

ArticleCancers2020

Inconsistent Intersample ALK FISH Results in Patients with Lung Cancer: Analysis of Potential Causes.

Zhenya Tang, Hui Chen, Lingzhi Hong, Guilin Tang, Gokce A Toruner, Wei Wang, Sinchita Roy Chowdhuri, Wei Yin, Hai Suk Jung, Jun Gu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Zhenya TangDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Hui ChenDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Lingzhi HongDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Guilin TangDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Gokce A TorunerDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Wei WangDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Sinchita Roy ChowdhuriDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Wei YinDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Hai Suk JungDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Jun GuDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Mark J RoutbortDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Jianjun ZhangDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Joseph D KhouryDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
L Jeffrey MedeirosDepartments of Hematopathology, Pathology and Thoracic/Head and Neck Medical Oncology, School of Health Professions, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ALK FISH analyses of multiple specimens occasionally yield inconsistent intersample results in lung cancer patients, posing clinical challenges requiring intensive analysis of all potential causative pre- and post- analytic factors. In this study, 19 patients (8M/11F) with inconsistent intersample ALK FISH results were analyzed, representing 4.9% of patients assessed ≥ twice in our institution. Fifteen patients received ALK tyrosine kinase inhibitor(s) (TKIs). Nine patients died, and ten were alive for 8 to 74-month follow-ups (median, 40 months). Through strict and stringent laboratory and case-review policies, all postanalytic factors were excluded. Correlating clinical information, ALK results obtained by RNA sequencing (RNA-seq) and other concurrent tests, several pre-analytic factors were determined. A suboptimal specimen was likely the cause in three patients, supported by the failure of one or more concurrent tests or discrepant results between FISH and RNA-seq. ALK inhibition by TKIs might have been responsible for the change of

Indexed as

ALKfluorescence in situ hybridization (FISH)lung cancernext-generation sequencing (NGS)RNA sequencing (RNA-seq)tyrosine kinase inhibitor (TKI)

Identifiers

PMID32674491
PMCPMC7409019
OpenAlexW3042894849

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.