Evidence map›Paper›PMID 32674489›Full record

ArticleViruses2020

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi.

Jasmine L Madrigal, Sutonuka Bhar, Samantha Hackett, Haley Engelken, Ross Joseph, Nemat O Keyhani, Melissa K Jones

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jasmine L MadrigalMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
Sutonuka BharMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
Samantha HackettMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
Haley EngelkenMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
Ross JosephMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
Nemat O KeyhaniMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
Melissa K JonesMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.
University of Florida · US

Funding

The impact of human norovirus interactions on commensal bacteriaR21AI140012 · NIAID · UNIVERSITY OF FLORIDA · PI JONES, MELISSA K · 2019 to 2020
$400k
NIAID NIH HHS R21 AI140012
6 · The paper itself

Abstract

The presence of commensal bacteria enhances both acute and persistent infection of murine noroviruses. For several enteric viral pathogens, mechanisms by which these bacteria enhance infection involve direct interactions between the virus and bacteria. While it has been demonstrated that human noroviruses bind to a variety of commensal bacteria, it is not known if this is also true for murine noroviruses. The goal of this study was to characterize interactions between murine noroviruses and commensal bacteria and determine the impact of bacterial growth conditions, incubation temperature and time, on murine norovirus attachment to microbes that comprise the mammalian microbiome. We show that murine noroviruses bind directly to commensal bacteria and show similar patterns of attachment as human norovirus VLPs examined under the same conditions. Furthermore, while binding levels are not impacted by the growth phase of the bacteria, they do change with time and incubation temperature. We also found that murine norovirus can bind to a commensal fungal species,

Indexed as

AnimalsBacteriaCaliciviridae InfectionsCandida albicansFungiGastroenteritisHumansMiceMicrobiotaMicroscopy, ElectronMycobiomeNorovirusSymbiosisfungal attachmentmurine norovirusnorovirusvirus–bacterial interaction

Identifiers

PMID32674489
PMCPMC7412252
OpenAlexW3043252710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.