ReviewCancers2020
Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis.
Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06701058 (Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer), which is not on this map. Cited by 43 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
Who cites it
43 citing papers in PubMed, 7 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Periodontal Disease and Incidence of Cancers: A Systematic Review and Meta-analysis of Cohort Studies.International dental journal · 2026Pooled it
- Investigating the Association Between Oral Hygiene and Oral Cancer: A Systematic Review and Meta-Analysis.Oral diseases · 2026Pooled it
- Risk of cancer in periodontal disease: an umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro data.Cancer metastasis reviews · 2025Pooled it
- Pooled it
- Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies.International journal of environmental research and public health · 2021Pooled it
- Smoking and Drinking Adjusted Association between Head and Neck Cancers and Oral Health Status Related to Periodontitis: a Meta-Analysis.Journal of Korean medical science · 2021Pooled it
- Exploring the associations between dietary nitrate and nitrite intake and markers of self-reported periodontal disease in the UK Biobank cohort.European journal of nutrition · 2026Article
- Oral Health-Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses.Community dentistry and oral epidemiology · 2026Article
- Periodontitis and Oral and Oropharyngeal Cancer Risk: A Systematic Review and Meta-Analysis with Exploratory Evidence on Tumor-AssociatedDentistry journal · 2026Review
- Oral hygiene and cancer risk: emerging evidence and public health perspectives.Discover oncology · 2026Review
- Clinical and laboratory biomarker correlates of lip, oral cavity, and pharyngeal cancer status in a large retrospective clinical database.Frontiers in oral health · 2026Article
- The systemic impact of periodontitis in about 100,000 patients: associations with heart diseases, cancer, and mortality.Clinical oral investigations · 2025Article
- Differences in oral health status between cancer patients: a case-control observational study.BMC oral health · 2025Observational
- Exploring the plausible genetic relationship of salivary and tongue microbiome with periodontitis: A mendelian randomization study.The Saudi dental journal · 2025Article
- Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma.Frontiers in oncology · 2025Article
- Feline oral squamous cell carcinoma: recent advances and future perspectives.Frontiers in veterinary science · 2025Review
- Analysis of the basement membrane-related genes ITGA7 and its regulatory role in periodontitis via machine learning: a retrospective study.BMC oral health · 2024Article
- Association between periodontal disease and systemic diseases: a cross-sectional analysis of current evidence.Military Medical Research · 2024Article
- Inflammation indices in association with periodontitis and cancer.Periodontology 2000 · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether "periodontal disease" can be considered as an independent risk factor for head and neck cancer (HNC) remains controversial. The aim of the current meta-analysis was to quantitatively assess this relationship in order to determine whether this represents a true risk factor, with implications for cancer prevention and management. PubMed, Scopus, and Embase databases were systematically searched. Selective studies were reviewed, and meta-analysis was performed to estimate the pooled odds ratio (OR) with 95% confidence intervals (CIs) on eligible studies using a random effects model. In total, 21 eligible observational studies (4 cohorts and 17 case-controls) were identified for qualitative synthesis after a review of 1051 articles. Significant heterogeneity could be identified in measures utilized for reporting of periodontal disease. Meta-analysis performed on nine studies that employed objective measures for reporting periodontal disease demonstrated a significant association between periodontal disease and HNC [OR 3.17, 95% CI, 1.78-5.64]. A diseased periodontium represents an independent risk marker, and a putative risk factor, for HNC. Prospective studies with standardized measures of periodontal disease severity and extent, integrated with microbiological and host susceptibility facets, are needed to elucidate the mechanisms of this positive association and whether treatment of the former influences the incidence and outcomes for HNC.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.